Cyclic peptides are an important drug modality but access to diverse chemical sets of cyclic peptides is difficult on a large library scale. Here, the authors use DNA-encoded library (DEL) technology for the dual-display of two peptidic sub-libraries at the extremities of DNA heteroduplexes and show that varying the level of conformational restraint is essential for the discovery of specific ligands for the three protein targets.
- Dimitar Petrov
- Louise Plais
- Jörg Scheuermann
