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Showing 1–3 of 3 results
Advanced filters: Author: Alicia Eckhardt Clear advanced filters

  • A human–SARS-CoV-2 protein interaction map highlights cellular processes that are hijacked by the virus and that can be targeted by existing drugs, including inhibitors of mRNA translation and predicted regulators of the sigma receptors.

    • David E. Gordon
    • Gwendolyn M. Jang
    • Nevan J. Krogan
    Research
    Nature
    Volume: 583, P: 459-468

  • Paediatric high-grade gliomas with MYCN amplification (HGG-MYCN) are rare and highly aggressive. Here, the authors generate a mouse model for HGG-MYCN that can recapitulate the histological and molecular profiles of the human tumours, and perform high-throughput drug screening to identify potential treatment options.

    • Melanie Schoof
    • Shweta Godbole
    • Ulrich Schüller
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Genome-wide analyses identify variants associated with sinus node dysfunction, distal conduction disease and pacemaker implantation, implicating ion channel function, cardiac developmental programs and sarcomeric structure in bradyarrhythmia susceptibility.

    • Lu-Chen Weng
    • Joel T. Rämö
    • Steven A. Lubitz
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 53-64