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Showing 1–2 of 2 results
Advanced filters: Author: Aliesha Garrett Clear advanced filters

  • Performing intravital imaging of the colon in mouse models is challenging due to the colon’s anatomic location and motility. Here, the authors develop a murine colonic window for intravital chronic imaging that maximises long-term animal survival and minimises motion artefacts.

    • Nikolai Rakhilin
    • Aliesha Garrett
    • Xiling Shen
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • Zhang et al. show that the poly(GA) proteins produced in patients with C9ORF72 repeat expansions cause neurodegeneration and behavioral abnormalities when expressed in mice. The emergence of these phenotypes requires poly(GA) aggregation, and poly(GA) inclusions sequester HR23 proteins involved in proteasomal degradation, as well as proteins involved in nucleocytoplasmic transport.

    • Yong-Jie Zhang
    • Tania F Gendron
    • Leonard Petrucelli
    Research
    Nature Neuroscience
    Volume: 19, P: 668-677