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Showing 1–3 of 3 results
Advanced filters: Author: Alin S. Tomoiaga Clear advanced filters

  • Identification of genes that determine and regulate cell identity remains challenging. Here, the authors use machine learning to identify cell identity genes and master regulator transcription factors based on gene expression profiles and histone modifications.

    • Bo Xia
    • Dongyu Zhao
    • Kaifu Chen
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Less is known about SARS-CoV-2 infection in unstudied geographical areas such as sub-Saharan Africa. Here the authors use multi-omics to characterize the immune response to SARS-CoV-2 in Uganda and consider how people living with HIV immunologically differentially respond to the virus.

    • Matthew J. Cummings
    • Barnabas Bakamutumaho
    • Max R. O’Donnell
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Epigenetically altered genes can have a key role in cancer pathobiology but epigenetic signatures that distinguish oncogenes are not yet known. Here, the authors identify broad genic repression domains, defined by widespread H3K27me3 modification, as an epigenetic signature to provide mutation-independent information for discovery of potential oncogenes.

    • Dongyu Zhao
    • Lili Zhang
    • Kaifu Chen
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14