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Advanced filters: Author: Alina Üffing Clear advanced filters

Accurate de novo design of high-affinity protein-binding macrocycles using deep learning

A method for de novo design of peptide macrocyles called RFpeptides has been developed. RFpeptides is an extension of RoseTTAFold2 and RFdiffusion and combines structure prediction and protein backbone generation for rapid and custom design of macrocyclic peptide binders.

Stephen A. Rettie
David Juergens
Gaurav Bhardwaj
ResearchOpen Access20 Jun 2025
Nature Chemical Biology

Volume: 21, P: 1948-1956
Targeting an alternative route: autophagy in RAS-driven cancers

Alina Üffing
Eleanor Attridge
Sharon A. Tooze
Research Highlights16 May 2025
Cell Research

Volume: 35, P: 389-390

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Accurate de novo design of high-affinity protein-binding macrocycles using deep learning

Targeting an alternative route: autophagy in RAS-driven cancers

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