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Showing 1–3 of 3 results
Advanced filters: Author: Alina Klems Clear advanced filters

  • Arterial flow regulates artery diameter but other mechanisms may also affect this. Here, the authors show that the guanine nucleotide exchange factor Trio and GTPases Rac1 and RhoG, triggers F-actin remodeling in arterial endothelial cells, independent of flow, to enhance lumen diameter in zebrafish and cell models.

    • Alina Klems
    • Jos van Rijssel
    • Ferdinand le Noble
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-20

  • The generation of vasculature in organs is regulated by cross-talk between the developing tissue and specialized endothelial cells. Here, the authors show that vessel growth feeding the zebrafish spinal cord is coordinated by balancing neuron-derived pro-angiogenic ligand Vegfaa and its receptor, sFlt1.

    • Raphael Wild
    • Alina Klems
    • Ferdinand le Noble
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-17

  • Stanicek et al identify a shear stress-induced long non-coding RNA they name LASSIE, which stabilises junctions between endothelial cells through interactions with junctional and cytoskeletal proteins. This study provides insights into how a transcript that does not encode a protein controls endothelial response to forces associated with blood flow and endothelial barrier function.

    • Laura Stanicek
    • Noelia Lozano-Vidal
    • Reinier Abraham Boon
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-13