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Showing 1–2 of 2 results
Advanced filters: Author: Alireza Ghanbarpour Clear advanced filters

  • AAA proteases must unfold substrates before degradation. Here the authors report cryo-EM structures to visualize how these machines achieve this by pulling the substrate tightly against their narrow axial channel and encircling the substrate’s folded domain using only the unfoldase’s flexible loops.

    • Alireza Ghanbarpour
    • Robert T. Sauer
    • Joseph H. Davis
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10

  • The translocation channel of ClpXP, which must open for degradation, is closed by an axial pore-2 loop when recognizing the ssrA degron. Here the authors show that the channel is also closed in the absence of substrate in cryo-EM structures and find that mutational destabilization of the closed-channel conformation changes substrate specificity.

    • Alireza Ghanbarpour
    • Steven E. Cohen
    • Robert T. Sauer
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-10