Nocturnin is a rhythmically expressed protein that regulates metabolism under the control of circadian clock proposed to function through the deadenylation of metabolic enzyme mRNAs. Here the authors show that Nocturnin and its fly homolog Curled catalyze the removal of 2′-phosphate from NADP+ and NADPH, providing a direct link to metabolic regulation.
- Michael A. Estrella
- Jin Du
- Alexei Korennykh
