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Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

Pathologically altered stromas are a common contributing factor to cancer progression and fibrogenesis. This report uncovers the role of LOXL2 in the creation and maintenance of the pathological microenvironment of human cancers and fibrotic diseases and presents the development of a LOXL2-specific antibody that shows therapeutic activity in tumor as well as lung and liver fibrosis models.

Vivian Barry-Hamilton
Rhyannon Spangler
Victoria Smith
Research05 Sept 2010
Nature Medicine

Volume: 16, P: 1009-1017
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry–mass spectrometry

A method for rapidly screening small-molecule inhibitors of amyloid assembly has been developed. This method uses electrospray ionization–ion mobility spectrometry–mass spectrometry to detect and identify the type of inhibition. A screen of this nature could help in the discovery of therapeutics for numerous diseases associated with aberrant protein aggregation.

Lydia M. Young
Janet C. Saunders
Alison E. Ashcroft
Research08 Dec 2014
Nature Chemistry

Volume: 7, P: 73-81
Ligand binding to distinct states diverts aggregation of an amyloid-forming protein

The aromatic compound rifamycin SV binds to expanded and partially compact assembly intermediates and inhibits amyloid fibril formation of β₂-microglobulin by diverting assembly toward soluble, toxic spherical aggregates lacking the classical structure of amyloid.

Lucy A Woods
Geoffrey W Platt
Sheena E Radford
Research28 Aug 2011
Nature Chemical Biology

Volume: 7, P: 730-739
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

Dinesh Aggarwal
Ben Warne
Ian G. Goodfellow
ResearchOpen Access08 Feb 2022
Nature Communications

Volume: 13, P: 1-16
Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission

Post-international travel quarantine has been widely implemented to mitigate SARS-CoV-2 transmission, but the impacts of such policies are unclear. Here, the authors used linked genomic and contact tracing data to assess the impacts of a 14-day quarantine on return to England in summer 2020.

Dinesh Aggarwal
Andrew J. Page
Ewan M. Harrison
ResearchOpen Access23 Feb 2022
Nature Communications

Volume: 13, P: 1-13
Inter-domain dynamics in the chaperone SurA and multi-site binding to its outer membrane protein clients

The chaperone SurA is involved in outer membrane protein (OMP) biogenesis in Gram-negative bacteria, but its mechanism of action is not fully understood. Combining mass spectrometric, biophysical and computational approaches, the authors here show how the conformational dynamics of SurA facilitate OMP binding.

Antonio N. Calabrese
Bob Schiffrin
Sheena E. Radford
ResearchOpen Access01 May 2020
Nature Communications

Volume: 11, P: 1-16
Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England

Genetic and testing data from England show that the SARS-CoV-2 variant of concern B.1.1.7 has a transmission advantage over other lineages.

Erik Volz
Swapnil Mishra
Neil M. Ferguson
Research25 Mar 2021
Nature

Volume: 593, P: 266-269
An in vivo platform to select and evolve aggregation-resistant proteins

Protein aggregation remains a significant challenge for manufacturing of protein biopharmaceuticals. Here, the authors demonstrate the use of directed evolution and an assay for in vivo innate protein aggregation-propensity to generate aggregation-resistant scFv fragments.

Jessica S. Ebo
Janet C. Saunders
David J. Brockwell
ResearchOpen Access14 Apr 2020
Nature Communications

Volume: 11, P: 1-12
Skp is a multivalent chaperone of outer-membrane proteins

Mass spectrometry, kinetics studies and in silico analyses indicate that multiple copies of the Skp chaperone are required for sequestration of 16-stranded or larger OMPs and prevention of their aggregation.

Bob Schiffrin
Antonio N Calabrese
Sheena E Radford
Research25 Jul 2016
Nature Structural & Molecular Biology

Volume: 23, P: 786-793
Lateral opening in the intact β-barrel assembly machinery captured by cryo-EM

The β-barrel assembly machinery (BAM complex) is a key mediator of outer membrane protein biogenesis in Gram-negative bacteria. Here the authors report a cryo-EM structure of the intact BAM complex that suggests that lateral gate opening is a necessary part of the BAM functional cycle.

Matthew G. Iadanza
Anna J. Higgins
Neil A. Ranson
ResearchOpen Access30 Sept 2016
Nature Communications

Volume: 7, P: 1-12
Secretory leukocyte protease inhibitor gene deletion alters bleomycin-induced lung injury, but not development of pulmonary fibrosis

Anthony N Habgood
Amanda L Tatler
Gisli Jenkins
Research14 Mar 2016
Laboratory Investigation

Volume: 96, P: 623-631
An in vivo platform for identifying inhibitors of protein aggregation

Applying an in vivo bacterial-based system for monitoring the influence of small molecules on the aggregation of model amyloid proteins expressed in the periplasm identified dopamine as a new inhibitor of hIAPP aggregation, a protein involved in type 2 diabetes mellitus.

Janet C Saunders
Lydia M Young
Sheena E Radford
Research14 Dec 2015
Nature Chemical Biology

Volume: 12, P: 94-101
GroEL accelerates the refolding of hen lysozyme without changing its folding mechanism

Joseph E. Coyle
Frieda L. Texter
Sheena E. Radford
Research01 Jul 1999
Nature Structural Biology

Volume: 6, P: 683-690
Plasma Tie2 is a tumor vascular response biomarker for VEGF inhibitors in metastatic colorectal cancer

Identification of response biomarkers is a key step towards the development of personalised care. Here, Jayson et al. identify plasma Tie2 as a biomarker for the response of the tumor vasculature to anti-angiogenics in patients with metastatic colorectal cancer, suggesting that monitoring Tie2 levels may help guide therapy in the clinics.

Gordon C. Jayson
Cong Zhou
Caroline Dive
ResearchOpen Access07 Nov 2018
Nature Communications

Volume: 9, P: 1-14
The hepatitis B virus preS1 domain hijacks host trafficking proteins by motif mimicry

Structural and thermodynamic characterization of the interaction between the intrinsically disordered HBV protein preS1 and the human adaptor protein γ2-EAR indicates that the viral protein imitates host cell interaction motifs to gain access to the cellular trafficking system.

Maike C Jürgens
Judit Vörös
Neil Ferguson
Research14 Jul 2013
Nature Chemical Biology

Volume: 9, P: 540-547
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E24
Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E23
Expanding the clinical spectrum of biglycan-related Meester-Loeys syndrome

Josephina A. N. Meester
Anne Hebert
Bart L. Loeys
ResearchOpen Access26 Mar 2024
npj Genomic Medicine

Volume: 9, P: 1-9
Hydrodynamics of the VanA-type VanS histidine kinase: an extended solution conformation and first evidence for interactions with vancomycin

Mary K. Phillips-Jones
Guy Channell
Stephen E. Harding
ResearchOpen Access11 Apr 2017
Scientific Reports

Volume: 7, P: 1-12
Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo

Claire L. Dobson
Paul W. A. Devine
David C. Lowe
ResearchOpen Access20 Dec 2016
Scientific Reports

Volume: 6, P: 1-14

Search

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

SARS-CoV-2 evolution during treatment of chronic infection

Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry–mass spectrometry

Ligand binding to distinct states diverts aggregation of an amyloid-forming protein

Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission

Inter-domain dynamics in the chaperone SurA and multi-site binding to its outer membrane protein clients

Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England

An in vivo platform to select and evolve aggregation-resistant proteins

Skp is a multivalent chaperone of outer-membrane proteins

Lateral opening in the intact β-barrel assembly machinery captured by cryo-EM

Secretory leukocyte protease inhibitor gene deletion alters bleomycin-induced lung injury, but not development of pulmonary fibrosis

An in vivo platform for identifying inhibitors of protein aggregation

GroEL accelerates the refolding of hen lysozyme without changing its folding mechanism

Plasma Tie2 is a tumor vascular response biomarker for VEGF inhibitors in metastatic colorectal cancer

The hepatitis B virus preS1 domain hijacks host trafficking proteins by motif mimicry

Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Expanding the clinical spectrum of biglycan-related Meester-Loeys syndrome

Hydrodynamics of the VanA-type VanS histidine kinase: an extended solution conformation and first evidence for interactions with vancomycin

Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo

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