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Showing 1–3 of 3 results
Advanced filters: Author: Alison E. Ringel Clear advanced filters

  • Ubiquitin-conjugating (E2) enzymes contain a conserved asparagine that has been proposed to stabilize an oxyanion intermediate. Structural and biochemical studies of Ubc13 suggest that this residue has a structural role in stabilizing the E2 active site.

    • Christopher E Berndsen
    • Reuven Wiener
    • Cynthia Wolberger
    Research
    Nature Chemical Biology
    Volume: 9, P: 154-156

  • Mutations of α2-Na/K ATPase can cause familial hemiplegic migraine via unclear mechanisms. Here, the authors show that deletion of α2-Na/K ATPase in astrocytes results in gene expression and metabolic changes leading to cortical spreading depression and episodic transient motor paralysis in mice.

    • Sarah E. Smith
    • Xiaoying Chen
    • Azad Bonni
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Ageing reshapes immune composition, function and regenerative capacity, with profound effects on tumour immunity, cancer progression and treatment outcomes. In this Review, Dolan and colleagues examine how age-resolved immunoprofiling, insights from ageing haematopoiesis and preclinical modelling are uncovering immune ageing dynamics and therapeutic challenges — revealing new opportunities to optimize cancer therapy across diverse age groups.

    • Melissa Dolan
    • Kendra A. Libby
    • Sandra S. McAllister
    Reviews
    Nature Reviews Cancer
    Volume: 25, P: 848-872