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Showing 1–5 of 5 results
Advanced filters: Author: Alison M. Condliffe Clear advanced filters

  • Dimethyl fumarate (DMF) is an anti-inflammatory drug proposed as a treatment for COVID19. Here the results are reported from a randomised trial testing DMF treatment in 713 patients hospitalised with COVID-19. DMF was not associated with any improvement in day 5 outcomes.

    • Peter Sandercock
    • Janet Darbyshire
    • Martin J. Landray
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Antibody mediated immune responses to Streptococcus pneumoniae are crucial for the immune response to infection. Here the authors show hyper-activation of PI3Kδ promotes development of a subset of B cells that exacerbate infection in an antibody-independent manner and can be reversed by therapeutic targeting in vivo.

    • Anne-Katrien Stark
    • Anita Chandra
    • Klaus Okkenhaug
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • Certain white blood cells home in on pathogens attacking the body by following gradients of chemoattractant to their targets. Cell movement in this chemotactic process requires extension of the cell's leading edge. That, it now emerges, stems from generation of lipid signals by an enzyme called phosphoinositide-3-OH kinase. The result is a highly polarized signalling cascade which leads to directed movement.

    • Alison M. Condliffe
    • Phillip T. Hawkins
    News & Views
    Nature
    Volume: 404, P: 135-137

  • Gain- and loss-of-function mutations in phosphoinositide 3-kinase-δ (PI3Kδ) result in a primary immunodeficiency syndrome termed APDS. Understanding the function of PI3Kδ in adaptive immune responses — from studies of mouse models of these mutations and from patients with APDS — provides new insights on how mutations in PI3Kδ promote immunodeficiencies.

    • Carrie L. Lucas
    • Anita Chandra
    • Klaus Okkenhaug
    Reviews
    Nature Reviews Immunology
    Volume: 16, P: 702-714