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Showing 1–7 of 7 results
Advanced filters: Author: Alistair S. Dunham Clear advanced filters

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Here the authors explore the ability of AlphaFold2 to predict structures across the human protein-protein interactome and the limitations thereof.

    • David F. Burke
    • Patrick Bryant
    • Arne Elofsson
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 216-225

  • Here, the authors evaluate the performance of AlphaFold2 and its predicted structures on common structural biological applications, including missense variants, function and ligand binding site prediction, modeling of interactions and modeling of experimental structural data.

    • Mehmet Akdel
    • Douglas E. V. Pires
    • Pedro Beltrao
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 29, P: 1056-1067

  • Results for the final phase of the 1000 Genomes Project are presented including whole-genome sequencing, targeted exome sequencing, and genotyping on high-density SNP arrays for 2,504 individuals across 26 populations, providing a global reference data set to support biomedical genetics.

    • Adam Auton
    • Gonçalo R. Abecasis
    • Gonçalo R. Abecasis
    ResearchOpen Access
    Nature
    Volume: 526, P: 68-74

  • Copy number variants (CNVs) account for a major proportion of human genetic diversity and may contribute to genetic susceptibility to disease. Here, a large, genome-wide study of association between common CNVs and eight common human diseases is presented. The study provides a wealth of technical insights that will inform future study design and analysis. The results also indicate that common CNVs that can be 'typed' on existing platforms are unlikely to contribute much to the genetic basis of common diseases.

    • Nick Craddock
    • Matthew E. Hurles
    • Peter Donnelly
    Research
    Nature
    Volume: 464, P: 713-720