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Showing 1–4 of 4 results
Advanced filters: Author: Aliya F. Spigelman Clear advanced filters

  • Insulin secretion adapts to metabolic needs, but how this happens over the short term is not clear. Here the authors show this involves upregulation of beta-cell exocytosis and requires the SUMO-protease SENP1, which responds to redox state in a zinc-dependent manner.

    • Haopeng Lin
    • Kunimasa Suzuki
    • Patrick E. MacDonald
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Insulin secretion from the pancreatic beta cell is a tightly regulated process that is vital for maintaining blood glucose homeostasis. Here, the authors show that the RNA binding protein RBFOX2 is a regulator of insulin secretion through the alternative splicing of genes required for insulin granule docking and exocytosis.

    • Nicole D. Moss
    • Kristen L. Wells
    • Lori Sussel
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Coding variants in peptidylglycine α-amidating monooxygenase (PAM) associated with type 2 diabetes risk negatively impact overall PAM activity via defects in expression and catalytic function, resulting in reduced insulin content and altered dynamics of insulin secretion.

    • Soren K. Thomsen
    • Anne Raimondo
    • Anna L. Gloyn
    Research
    Nature Genetics
    Volume: 50, P: 1122-1131