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Showing 1–3 of 3 results

Advanced filters: Author: Alla Mitrofanova Clear advanced filters

Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease

This study describes a class of small molecule compounds that promote ABCA1-dependent cholesterol efflux via a non-transcriptional mechanism, the identification of the molecular target by a chemical biology approach, and the potential of these agents for the treatment of chronic kidney diseases and potentially other diseases where lipid accumulation drives disease progression.

Matthew B. Wright
Javier Varona Santos
Alessia Fornoni
ResearchOpen Access02 Aug 2021
Nature Communications

Volume: 12, P: 1-14
Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease

Chronic kidney disease is characterized by dyslipidaemia and lipid accumulation in the kidney. In this Review, the authors examine the evidence that links alterations in lipid metabolism to kidney injury and progression of kidney disease, and explore potential lipid-targeted therapeutic approaches.

Alla Mitrofanova
Sandra Merscher
Alessia Fornoni
Reviews27 Jul 2023
Nature Reviews Nephrology

Volume: 19, P: 629-645
ABCA1 deficiency contributes to podocyte pyroptosis priming via the APE1/IRF1 axis in diabetic kidney disease

Marie Ito
Gloria Michelle Ducasa
Alessia Fornoni
ResearchOpen Access14 Jun 2023
Scientific Reports

Volume: 13, P: 1-14

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