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Showing 1–3 of 3 results
Advanced filters: Author: Allen Blevins Clear advanced filters

  • Identifying leukaemia stem cells (LSC) and defining how they drive tumourigenesis might aid in the treatment of disease. Here, the authors show that a reporter Musashi 2 can serve as a platform to effectively identify leukemic stem cells and it is used to define Syndecan-1 as a dependency for these aggressive, therapy resistant cells.

    • Kyle Spinler
    • Jeevisha Bajaj
    • Tannishtha Reya
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • It is difficult to image haematopoietic stem cells (HSC) in their niche. Here, the authors present a new high-throughput computational approach to visualise HSCs in vivoat a high spatial and temporal resolution and also use a Msi2-reporter to label endogenous HSCs and progenitors, enabling cell tracking

    • Claire S. Koechlein
    • Jeffrey R. Harris
    • Tannishtha Reya
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • Tannishtha Reya and colleagues show that Lis1, a key mediator of asymmetric cell division, is required for blood formation and hematopoietic stem cell function. The authors also show that the directed control of asymmetric division is a critical regulator of malignant hematopoietic development.

    • Bryan Zimdahl
    • Takahiro Ito
    • Tannishtha Reya
    Research
    Nature Genetics
    Volume: 46, P: 245-252