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Showing 1–6 of 6 results
Advanced filters: Author: Allette Kimaada Clear advanced filters

  • Characterization of HIV infection at the cellular level is important to understand the molecular forces maintaining the latent reservoir and productive infection in T cells. Here authors describe the pathways that are governing these T cell states across the T lineage via a humanized mouse model allowing precise labeling of the HIV-infected cells coupled to single cell RNA sequencing.

    • Namita Satija
    • Foramben Patel
    • Benjamin K. Chen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Human embryo development involves extensive transcriptional remodeling. In this study, the authors apply long- and short-read RNA-Seq to profile the transcriptomes of 73 human preimplantation embryos spanning zygotic to blastocyst stages, identifying tens of thousands of additional isoforms transcribed from both known and unannotated gene loci.

    • Denis Torre
    • Nancy J. Francoeur
    • Robert Sebra
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-23

  • Late prenatal development of the human neocortex encompasses a critical period of gliogenesis and cortical expansion. Here, authors use human transcriptomics to capture transience and diversity of cells in middle and late prenatal development, including glial progenitor signatures.

    • Susana I. Ramos
    • Zarmeen M. Mussa
    • Nadejda M. Tsankova
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • Influenza A virus (IAV) infection induces transcription termination defects in host cells, an effect modulated by SUMOylation of an intrinsically disordered region of the influenza NS1 protein expressed by the 1918 pandemic IAV strain.

    • Nan Zhao
    • Vittorio Sebastiano
    • Ivan Marazzi
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 885-893

  • Immune-mediated selection pressures impact the clonal evolution of tumours. Here, in hepatocellular carcinoma the authors map spatio-temporal interactions between tumor and immune cells, highlighting the regulatory substrate of intra-tumoural heterogeneity that correlates with regional adaptive immune responses.

    • Bojan Losic
    • Amanda J. Craig
    • Augusto Villanueva
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15