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Showing 1–5 of 5 results
Advanced filters: Author: Allison P. Siegenfeld Clear advanced filters

  • Here the authors developed ‘Lamina-Inducible Methylation and Hi-C’ (LIMe-Hi-C) to simultaneously measure chromosome conformation, DNA methylation, and nuclear lamina positioning. Application of the method revealed dynamic changes upon PRC2 inhibition and an essential function of H3K27me3 in regulating sub-compartments and lamina association.

    • Allison P. Siegenfeld
    • Shelby A. Roseman
    • Brian B. Liau
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • A CRISPR–Cas9 screening-based structure–activity relationship profiling method reveals that LSD1 inhibitors suppress acute myeloid leukemia by disruption of the interaction between LSD1 and GFI1B instead of the enzyme activity of LSD1.

    • Michael E. Vinyard
    • Cindy Su
    • Brian B. Liau
    Research
    Nature Chemical Biology
    Volume: 15, P: 529-539

  • The authors reveal that the chromatin architectural proteins CTCF and RAD21 organize DNA around nuclear speckles to enhance gene induction. This structural organization, when disrupted as in Cornelia de Lange syndrome, impairs key gene functions, providing insight into potential disease mechanisms.

    • Ruofan Yu
    • Shelby Roseman
    • Shelley L. Berger
    Research
    Nature Structural & Molecular Biology
    Volume: 32, P: 1069-1080

  • Profiling the resistance landscape to PRC2 inhibitors in EZH2-mutant lymphoma with CRISPR-suppressor scanning reveals drug addiction mutations and a repressive methylation ceiling. Surpassing the ceiling with SETD2 inhibition halts lymphoma growth.

    • Hui Si Kwok
    • Allyson M. Freedy
    • Brian B. Liau
    Research
    Nature Chemical Biology
    Volume: 19, P: 1105-1115