Nature Search

KCNQ channel openers reverse depressive symptoms via an active resilience mechanism

Potassium channels in the ventral tegmental area are known to regulate resilience against stress-induced depression. Here, the authors show over expression of KCNQ3 channels in VTA dopaminergic neurons or treatment with KCNQ channel openers normalizes depressive behaviours in mouse models.

Allyson K. Friedman
Barbara Juarez
Ming-Hu Han
ResearchOpen Access24 May 2016
Nature Communications

Volume: 7, P: 1-7
Serotonergic modulation of the BNST–CeA pathway reveals sex differences in fear learning

Ravenelle et al. show that systematically increasing serotonin has sex-specific effects on fear learning in mice. In females only, increasing serotonin in the BNST enhances fear memory by promoting communication with the amygdala.

Rebecca Ravenelle
Jinah Lee
Nesha S. Burghardt
Research06 Aug 2025
Nature Neuroscience

Volume: 28, P: 1897-1909
Correction: Corrigendum: Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling

Boxing Li
Wei Jie
Tian-Ming Gao
Amendments and Corrections21 Nov 2014
Nature Neuroscience

Volume: 17, P: 1841
Urbanisation generates multiple trait syndromes for terrestrial animal taxa worldwide

Cities may host surprisingly diverse and functionally distinct biological communities. This global analysis on 5302 vertebrate and invertebrate species finds evidence of 4 trait syndromes in urban animal assemblages, modulated by spatial and geographic factors.

Amy K. Hahs
Bertrand Fournier
Marco Moretti
ResearchOpen Access07 Aug 2023
Nature Communications

Volume: 14, P: 1-14
Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway

Chronic social-defeat stress increases phasic firing of ventral tegmental area (VTA) neurons and increases the amount of BDNF in the nucleus accumbens (NAc). The authors show that increased activity of NAc-projecting VTA neurons is sufficient to increase the amount of BDNF in the NAc, an effect that depends on CRF signaling in the NAc.

Jessica J Walsh
Allyson K Friedman
Ming-Hu Han
Research24 Nov 2013
Nature Neuroscience

Volume: 17, P: 27-29
Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors

Anxiety and depression are highly comorbid, yet the distinct or shared neurobiological correlates of anxiety remain elusive. Here, Morel et al. define that the midbrain projection to the basolateral amygdala control anxiety but not depression.

Carole Morel
Sarah E. Montgomery
Ming-Hu Han
ResearchOpen Access22 Mar 2022
Nature Communications

Volume: 13, P: 1-13
Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome

The molecular mechanisms underlying deficits in Down syndrome remain unclear. Here, the authors show that copy number restoration of a chromatin remodeler in trisomic mice is sufficient to rescue epigenomic, physiological and cognitive deficits.

Sasha L. Fulton
Wendy Wenderski
Ian Maze
ResearchOpen Access26 Oct 2022
Nature Communications

Volume: 13, P: 1-17
Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling

Nuclear calcium levels affect gene expression, but little is known about how they are regulated. The authors show that large-conductance calcium-activated potassium (BK) channels are present on the nuclear envelope in rodent hippocampal neurons. Blockade of nuclear BK channels revealed that they regulate nucleoplasmic Ca²⁺, gene expression and dendritic arborization.

Boxing Li
Wei Jie
Tian-Ming Gao
Research22 Jun 2014
Nature Neuroscience

Volume: 17, P: 1055-1063
Midbrain circuit regulation of individual alcohol drinking behaviors in mice

Mice exposed to a two-bottle alcohol choice paradigm can be divided into high and low drinking groups. Here, the authors show that stimulating VTA neurons to induce higher phasic activity patterns that are observed in low alcohol drinking mice, suppresses alcohol drinking in mice that are high alcohol drinking.

Barbara Juarez
Carole Morel
Ming-Hu Han
ResearchOpen Access20 Dec 2017
Nature Communications

Volume: 8, P: 1-15
Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes

An integrated analysis of de novo and inherited coding variants in 42,607 individuals with autism spectrum disorder identifies 60 risk genes of which five have not previously been associated with neurodevelopmental disorders.

Xueya Zhou
Pamela Feliciano
Wendy K. Chung
ResearchOpen Access18 Aug 2022
Nature Genetics

Volume: 54, P: 1305-1319
HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity

The authors show that chronic treatment with antipsychotic drugs decreases expression of mGlu2 and histone acetylation at its promoter in frontal cortex. This is mediated through 5-HT2A receptor–dependent upregulation of HDAC2. HDAC inhibitors prevent this decrease in mGluR2, augmenting the behavioral effects of antipsychotics.

Mitsumasa Kurita
Terrell Holloway
Javier González-Maeso
Research05 Aug 2012
Nature Neuroscience

Volume: 15, P: 1245-1254
Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons

Optogenetic induction of phasic, but not tonic, firing in VTA dopamine neurons induces susceptibility to stress in mice undergoing a subthreshold social-defeat paradigm and in previously resilient mice that have been subjected to repeated social-defeat stress, and this effect is projection-pathway specific.

Dipesh Chaudhury
Jessica J. Walsh
Ming-Hu Han
Research12 Dec 2012
Nature

Volume: 493, P: 532-536
Author Correction: Midbrain circuit regulation of individual alcohol drinking behaviors in mice

Barbara Juarez
Carole Morel
Ming-Hu Han
Amendments and CorrectionsOpen Access08 Feb 2018
Nature Communications

Volume: 9, P: 1
Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress

Chronic social stress has adverse behavioral consequences and can result in the development of depression in humans. Using a rodent social stress model, we report increased synaptic connectivity between the thalamus and striatum in susceptible mice that controls behavioral coping mechanisms relevant to depression.

Daniel J Christoffel
Sam A Golden
Scott J Russo
Research01 Jun 2015
Nature Neuroscience

Volume: 18, P: 962-964
Stable to improved cardiac and pulmonary function in children with high-risk sickle cell disease following haploidentical stem cell transplantation

Deborah Friedman
Allen J. Dozor
Mitchell S. Cairo
Research06 May 2021
Bone Marrow Transplantation

Volume: 56, P: 2221-2230
Effects of the KCNQ channel opener ezogabine on functional connectivity of the ventral striatum and clinical symptoms in patients with major depressive disorder

Aaron Tan
Sara Costi
James W. Murrough
Research01 Nov 2018
Molecular Psychiatry

Volume: 25, P: 1323-1333
The human body at cellular resolution: the NIH Human Biomolecular Atlas Program

HuBMAP supports technology development, data acquisition, and spatial analyses to generate comprehensive molecular and cellular three-dimensional tissue maps.

Michael P. Snyder
Shin Lin
James Anderson
ReviewsOpen Access09 Oct 2019
Nature

Volume: 574, P: 187-192
Revised diagnostic criteria for neurofibromatosis type 1 and Legius syndrome: an international consensus recommendation

Eric Legius
Ludwine Messiaen
Scott R. Plotkin
ResearchOpen Access19 May 2021
Genetics in Medicine

Volume: 23, P: 1506-1513

Search

KCNQ channel openers reverse depressive symptoms via an active resilience mechanism

Serotonergic modulation of the BNST–CeA pathway reveals sex differences in fear learning

Correction: Corrigendum: Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling

Urbanisation generates multiple trait syndromes for terrestrial animal taxa worldwide

Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway

Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors

Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome

Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling

Midbrain circuit regulation of individual alcohol drinking behaviors in mice

Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes

HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity

Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons

Author Correction: Midbrain circuit regulation of individual alcohol drinking behaviors in mice

Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress

Stable to improved cardiac and pulmonary function in children with high-risk sickle cell disease following haploidentical stem cell transplantation

Effects of the KCNQ channel opener ezogabine on functional connectivity of the ventral striatum and clinical symptoms in patients with major depressive disorder

The human body at cellular resolution: the NIH Human Biomolecular Atlas Program

Revised diagnostic criteria for neurofibromatosis type 1 and Legius syndrome: an international consensus recommendation

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