Nature Search

Fast nanomechanical spectroscopy of soft matter

It is desirable to have a microscopy technique that is non-invasive and able to provide high spatial resolution mapping of materials. Here Herruzo et al. develop a multifrequency force microscopy that enables simultaneous nanoscale mapping of mechanical spectra of soft matter surfaces.

Elena T. Herruzo
Alma P. Perrino
Ricardo Garcia
Research20 Jan 2014
Nature Communications

Volume: 5, P: 1-8
Snf7 spirals sense and alter membrane curvature

Snf7 is the major component of the ESCRTIII membrane deformation system. Here, the authors used high-speed AFM to study Snf7 on nano-patterned and soft supports and show that loaded Snf7 spiral springs are curvature sensitive and deform membranes.

Nebojsa Jukic
Alma P. Perrino
Simon Scheuring
ResearchOpen Access21 Apr 2022
Nature Communications

Volume: 13, P: 1-17
Single molecule kinetics of bacteriorhodopsin by HS-AFM

Here, the authors use high-speed atomic force microscopy (HS-AFM) methods to characterize the single molecule kinetics of wild-type bacteriorhodopsin (bR) with millisecond temporal resolution, providing new insights into the bR conformational cycle.

Alma P. Perrino
Atsushi Miyagi
Simon Scheuring
ResearchOpen Access10 Dec 2021
Nature Communications

Volume: 12, P: 1-10
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

A cross-ancestry genome-wide association meta-analysis of amyotrophic lateral sclerosis (ALS) including 29,612 patients with ALS and 122,656 controls identifies 15 risk loci with distinct genetic architectures and neuron-specific biology.

Wouter van Rheenen
Rick A. A. van der Spek
Jan H. Veldink
ResearchOpen Access06 Dec 2021
Nature Genetics

Volume: 53, P: 1636-1648
A stem cell roadmap of ribosome heterogeneity reveals a function for RPL10A in mesoderm production

How ribosomes differ in composition and function to regulate gene expression is poorly understood. Here, the authors show that ribosome composition changes during stem cell differentiation and identify a ribosomal protein that regulates production of the mesoderm lineage.

Naomi R. Genuth
Zhen Shi
Maria Barna
ResearchOpen Access19 Sept 2022
Nature Communications

Volume: 13, P: 1-19
Fast and high-resolution mapping of elastic properties of biomolecules and polymers with bimodal AFM

This protocol describes how to generate high-resolution maps of the elastic properties of biomolecules and polymers using bimodal AFM. The procedure covers sample preparation, bimodal AFM setup and calibration, and data acquisition and processing.

Simone Benaglia
Victor G. Gisbert
Ricardo Garcia
Protocols16 Nov 2018
Nature Protocols

Volume: 13, P: 2890-2907
Determinants of weight, psychological status, food contemplation and lifestyle changes in patients with obesity during the COVID-19 lockdown: a nationwide survey using multiple correspondence analysis

A. Caretto
S. Pintus
L. Messeri
ResearchOpen Access19 Mar 2022
International Journal of Obesity

Volume: 46, P: 1280-1287
Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Wouter van Rheenen
Rick A. A. van der Spek
Jan H. Veldink
Amendments and CorrectionsOpen Access31 Jan 2022
Nature Genetics

Volume: 54, P: 361

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