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Showing 1–7 of 7 results
Advanced filters: Author: Alper Kucukural Clear advanced filters

  • Dissecting the causal relationship between genotype and phenotype can be challenging, Here, the authors develop Worm Perturb-Seq, a high throughput sequencing and analytical framework to assess transcriptomic changes upon gene perturbation in whole C. elegans.

    • Hefei Zhang
    • Xuhang Li
    • Albertha J. M. Walhout
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21

  • The feasibility of adeno-associated-virus-delivered nonsense suppressor tRNAs operating on premature termination codons (AAV-NoSTOP) is explored to restore gene function, using a mouse model of mucopolysaccharidosis type I for proof of concept.

    • Jiaming Wang
    • Yue Zhang
    • Dan Wang
    Research
    Nature
    Volume: 604, P: 343-348

  • HIV-1 infection is associated with persistent inflammation that can contribute to a variety of comorbidities. Luban and colleagues demonstrate that HIV-1 infection results in permanent depletion of innate lymphoid cells, leading to breakdown of gut barrier function and a feed-forward inflammation loop, which includes skewing of NK cells toward an inflammatory/memory phenotype.

    • Yetao Wang
    • Lawrence Lifshitz
    • Jeremy Luban
    Research
    Nature Immunology
    Volume: 21, P: 274-286

  • Human Staufen1 (Stau1) is a double-stranded RNA-binding protein implicated in various post-transcriptional gene-regulatory processes. Genome-wide mapping of Stau1-binding sites, combined with Stau1 knockdown and overexpression analyses, has revealed a new role for Stau1 in regulating translation of GC-rich mRNAs by sensing overall transcript secondary structure.

    • Emiliano P Ricci
    • Alper Kucukural
    • Melissa J Moore
    Research
    Nature Structural & Molecular Biology
    Volume: 21, P: 26-35