This study detects Chlamydia pneumoniae in human retina and brain, increasing with AD severity. Retinal pathogen load with Aβ42 may predict AD stage. In models, infection drives Aβ deposition and NLRP3 activation, worsening pathology and cognition.
- Bhakta Prasad Gaire
- Yosef Koronyo
- Maya Koronyo-Hamaoui