Nature Search

Influenza vaccines promote humoral and cellular immune responses: a randomized, double-blind, phase 3 trial

The authors report a trial subset analysis of the immune responses induced by two inactivated quadrivalent influenza vaccines (QIVs): Sinovac QIV and Vaxigrip-Tetra™. Both vaccines elicit robust humoral responses and distinct T cell profiles.

Linmar Rodríguez-Guilarte
Constanza Méndez
Alexis M. Kalergis
ResearchOpen Access07 Dec 2025
Nature Communications

Volume: 17, P: 1-14
β-lactamase expression induces collateral sensitivity in Escherichia coli

In this work, authors show that β-lactamase enzymes not only confer antibiotic resistance but also increase susceptibility to other antibiotics.

Cristina Herencias
Laura Álvaro-Llorente
Jerónimo Rodríguez-Beltrán
ResearchOpen Access03 Jun 2024
Nature Communications

Volume: 15, P: 1-11
Plasmid-mediated phenotypic noise leads to transient antibiotic resistance in bacteria

In this work, authors combine computational models with single-cell and population-level data showing the variability in plasmid copy number within bacterial populations leads to phenotypic diversity. They reveal how multicopy plasmids contribute to bacterial transient antibiotic resistance.

J. Carlos R. Hernandez-Beltran
Jerónimo Rodríguez-Beltrán
Rafael Peña-Miller
ResearchOpen Access23 Mar 2024
Nature Communications

Volume: 15, P: 1-13
Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation

Trade-offs are common during evolutionary innovation. Here, the authors show that multicopy plasmids allow coexistence of the ancestral and evolved alleles in the TEM-1 β-lactamase system, helping bacteria to escape evolutionary constraints imposed by trade-offs.

Jeronimo Rodriguez-Beltran
J. Carlos R. Hernandez-Beltran
Alvaro San Millan
Research09 Apr 2018
Nature Ecology & Evolution

Volume: 2, P: 873-881
Pathogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndrome

SPTBN1 mutations cause a neurodevelopmental syndrome characterized by intellectual disability, language and motor delays, autism, seizures and other features. The variants disrupt βII-spectrin function and disturb cytoskeletal organization and dynamics.

Margot A. Cousin
Blake A. Creighton
Damaris N. Lorenzo
Research01 Jul 2021
Nature Genetics

Volume: 53, P: 1006-1021
Scalable synthesis of NiFe-layered double hydroxide for efficient anion exchange membrane electrolysis

Green hydrogen production via water electrolysis requires a low-cost solution to provide efficient catalysts. Here, the authors report an industrially scalable method for synthesizing NiFe layered double hydroxide at room temperature and atmospheric pressure, enhancing alkaline electrolysis.

Alvaro Seijas-Da Silva
Adrian Hartert
Gonzalo Abellán
ResearchOpen Access03 Jul 2025
Nature Communications

Volume: 16, P: 1-17
Plasmid-encoded insertion sequences promote rapid adaptation in clinical enterobacteria

Combining experimental and within-patient evolution analyses, the authors show that the widespread conjugative plasmid pOXA-48 promotes bacterial evolution through the transposition of plasmid-encoded insertion sequence IS1 elements.

Jorge Sastre-Dominguez
Javier DelaFuente
Alvaro San Millan
Research28 Aug 2024
Nature Ecology & Evolution

Volume: 8, P: 2097-2112
The m⁶A reader YTHDC1 and the RNA helicase DDX5 control the production of rhabdomyosarcoma-enriched circRNAs

Rhabdomyosarcoma (RMS) is the most diffused soft tissue sarcoma in children and adolescents. Herein, the authors identify the m⁶A machinery and the RNA helicase DDX5 as factors responsible for the increase of a subset of circRNAs in RMS, providing protein and RNA candidates for the study of its tumorigenicity.

Dario Dattilo
Gaia Di Timoteo
Irene Bozzoni
ResearchOpen Access05 Apr 2023
Nature Communications

Volume: 14, P: 1-15
Beyond horizontal gene transfer: the role of plasmids in bacterial evolution

Recent studies have revealed that the evolutionary impact of plasmids goes above and beyond their being mere gene delivery platforms. In this Review, Rodríguez-Beltrán, San Millán and colleagues discuss the advances that underscore the importance of plasmids in bacterial ecology and evolution beyond horizontal gene transfer.

Jerónimo Rodríguez-Beltrán
Javier DelaFuente
Álvaro San Millán
Reviews19 Jan 2021
Nature Reviews Microbiology

Volume: 19, P: 347-359
Within-patient evolution of plasmid-mediated antimicrobial resistance

A combination of analysis of plasmid diversity in the gut of hospitalized patients with experimental evolution shows that the evolution of plasmid-mediated antibiotic resistance involves a trade-off between antibiotic resistance levels and bacterial fitness.

Javier DelaFuente
Laura Toribio-Celestino
Alvaro San Millan
Research27 Oct 2022
Nature Ecology & Evolution

Volume: 6, P: 1980-1991
The global environmental footprint of Switzerland’s net-zero energy system uncovers impacts abroad

Even if domestic greenhouse gas emissions were reduced to net zero in Switzerland by 2050, 2 to 5 megatonnes of carbon dioxide equivalent per year could persist abroad due to imports and energy-related infrastructure needs, according to a life cycle assessment of model simulations.

Alvaro Jose Hahn Menacho
Romain Sacchi
Peter Burgherr
ResearchOpen Access05 Apr 2025
Communications Earth & Environment

Volume: 6, P: 1-14
Pentraxin-3 is a candidate biomarker on the spectrum of severity from pre-eclampsia to HELLP syndrome: GenPE study

Claudia C. Colmenares-Mejía
Doris C. Quintero-Lesmes
Norma Serrano Díaz
Research13 Apr 2020
Hypertension Research

Volume: 43, P: 884-891
Pervasive transmission of a carbapenem resistance plasmid in the gut microbiota of hospitalized patients

Modelling combined with epidemiological and genomic data analysis from a hospital in Spain reveals frequent transmission of high-risk pOXA-48-carrying enterobacteria clones between patients and horizontal transfer of pOXA-48 plasmid within patients.

Ricardo León-Sampedro
Javier DelaFuente
Álvaro San Millán
Research29 Mar 2021
Nature Microbiology

Volume: 6, P: 606-616
Variability of plasmid fitness effects contributes to plasmid persistence in bacterial communities

The variability of plasmid fitness effects on wild-type bacterial hosts have been largely unknown until this study, which shows that plasmid persistence increases with bacterial diversity and becomes less dependent on conjugation. This could explain why plasmids remain so common in nature.

Aida Alonso-del Valle
Ricardo León-Sampedro
Alvaro San Millán
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-14
Lognormals, power laws and double power laws in the distribution of frequencies of harmonic codewords from classical music

Marc Serra-Peralta
Joan Serrà
Álvaro Corral
ResearchOpen Access16 Feb 2022
Scientific Reports

Volume: 12, P: 1-14
Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis

Frances M. Bashore
Ariana B. Marquez
Alison D. Axtman
ResearchOpen Access14 Apr 2023
Scientific Reports

Volume: 13, P: 1-17
Calcium cytotoxicity sensitizes prostate cancer cells to standard-of-care treatments for locally advanced tumors

Alessandro Alaimo
Marco Lorenzoni
Andrea Lunardi
ResearchOpen Access07 Dec 2020
Cell Death & Disease

Volume: 11, P: 1-17
Centromeric AA motif in KIR as an optimal surrogate marker for precision definition of alloimmune reproductive failure

Raquel Gil Laborda
Edgard Rodríguez de Frías
Silvia Sánchez-Ramón
ResearchOpen Access09 Feb 2024
Scientific Reports

Volume: 14, P: 1-10
Beneficial effect of temporary methotrexate interruption on B and T cell responses upon SARS-CoV-2 vaccination in patients with rheumatoid arthritis or psoriatic arthritis

Pedro Martínez-Fleta
Esther F. Vicente-Rabaneda
Santos Castañeda
ResearchOpen Access30 Jan 2024
npj Vaccines

Volume: 9, P: 1-9
Sphk2 deletion is involved in structural abnormalities and Th17 response but does not aggravate colon inflammation induced by sub-chronic stress

David Martín-Hernández
Irene L. Gutiérrez
Luis Menchén
ResearchOpen Access08 Mar 2022
Scientific Reports

Volume: 12, P: 1-16
Dominance style predicts differences in food retrieval strategies

Jose Luis Gomez-Melara
Rufino Acosta-Naranjo
Federica Amici
ResearchOpen Access01 Feb 2021
Scientific Reports

Volume: 11, P: 1-9
Dominance style only partially predicts differences in neophobia and social tolerance over food in four macaque species

Federica Amici
Anja Widdig
Bonaventura Majolo
ResearchOpen Access16 Dec 2020
Scientific Reports

Volume: 10, P: 1-10
Virological outcome among HIV infected patients transferred from pediatric care to adult units in Madrid, Spain (1997–2017)

Carolina Beltrán-Pavez
Miguel Gutiérrez-López
Elisa Lazzari
ResearchOpen Access09 Oct 2020
Scientific Reports

Volume: 10, P: 1-13
Plasma androgen receptor and serum chromogranin A in advanced prostate cancer

Vincenza Conteduca
Emanuela Scarpi
Ugo De Giorgi
ResearchOpen Access18 Oct 2018
Scientific Reports

Volume: 8, P: 1-8
Risk factors for developing ventilator-associated lower respiratory tract infection in patients with severe COVID-19: a multinational, multicentre study, prospective, observational study

Luis Felipe Reyes
Alejandro Rodriguez
Neus Guasch
ResearchOpen Access21 Apr 2023
Scientific Reports

Volume: 13, P: 1-15

Search

Influenza vaccines promote humoral and cellular immune responses: a randomized, double-blind, phase 3 trial

β-lactamase expression induces collateral sensitivity in Escherichia coli

Plasmid-mediated phenotypic noise leads to transient antibiotic resistance in bacteria

Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation

Pathogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndrome

Scalable synthesis of NiFe-layered double hydroxide for efficient anion exchange membrane electrolysis

Plasmid-encoded insertion sequences promote rapid adaptation in clinical enterobacteria

The m⁶A reader YTHDC1 and the RNA helicase DDX5 control the production of rhabdomyosarcoma-enriched circRNAs

Beyond horizontal gene transfer: the role of plasmids in bacterial evolution

Within-patient evolution of plasmid-mediated antimicrobial resistance

The global environmental footprint of Switzerland’s net-zero energy system uncovers impacts abroad

Pentraxin-3 is a candidate biomarker on the spectrum of severity from pre-eclampsia to HELLP syndrome: GenPE study

Pervasive transmission of a carbapenem resistance plasmid in the gut microbiota of hospitalized patients

Variability of plasmid fitness effects contributes to plasmid persistence in bacterial communities

Lognormals, power laws and double power laws in the distribution of frequencies of harmonic codewords from classical music

Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis

Calcium cytotoxicity sensitizes prostate cancer cells to standard-of-care treatments for locally advanced tumors

Centromeric AA motif in KIR as an optimal surrogate marker for precision definition of alloimmune reproductive failure

Beneficial effect of temporary methotrexate interruption on B and T cell responses upon SARS-CoV-2 vaccination in patients with rheumatoid arthritis or psoriatic arthritis

Sphk2 deletion is involved in structural abnormalities and Th17 response but does not aggravate colon inflammation induced by sub-chronic stress

Dominance style predicts differences in food retrieval strategies

Dominance style only partially predicts differences in neophobia and social tolerance over food in four macaque species

Virological outcome among HIV infected patients transferred from pediatric care to adult units in Madrid, Spain (1997–2017)

Plasma androgen receptor and serum chromogranin A in advanced prostate cancer

Risk factors for developing ventilator-associated lower respiratory tract infection in patients with severe COVID-19: a multinational, multicentre study, prospective, observational study

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