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Showing 1–5 of 5 results
Advanced filters: Author: Alvaro Ingles-Prieto Clear advanced filters

  • SPNS2 exports S1P and FTY720-P to control immune cell migration. Here, the authors use cryo-EM, immunofluorescence, in vitro binding and in vivo S1P export, and MD simulations to uncover the mechanisms of SPNS2’s transport and inhibition.

    • Huanyu Z. Li
    • Ashley C. W. Pike
    • David B. Sauer
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • The combination of a light-activated receptor tyrosine kinase and a fluorescent MAPK/ERK reporter results in the development of an optogenetics-based cell screening method to identify small-molecule inhibitors of RTK signaling.

    • Álvaro Inglés-Prieto
    • Eva Reichhart
    • Harald Janovjak
    Research
    Nature Chemical Biology
    Volume: 11, P: 952-954

  • A set of CRISPR–Cas9-based genetic screens in a haploid human cell line identifies more than 200 gene–drug associations involving solute carriers (SLCs), transporters important for the uptake and activity of cytotoxic drugs.

    • Enrico Girardi
    • Adrián César-Razquin
    • Giulio Superti-Furga
    Research
    Nature Chemical Biology
    Volume: 16, P: 469-478

  • Using phylogenetic analysis, ancestral forms of thioredoxin reflecting the sequences likely to have existed at key evolutionary points have now been synthesized and analyzed. Single-molecule analysis indicates that all of the reconstructed enzymes use the extant reaction mechanism but that the most ancient are optimally active at low pH and resistant to higher temperatures, conditions that would have existed on early earth.

    • Raul Perez-Jimenez
    • Alvaro Inglés-Prieto
    • Julio M Fernandez
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 592-596

  • The Innovative Medicines Initiative Consortium RESOLUTE has started to develop tools and produce data sets to de-orphanize transporters in the solute carrier protein (SLC) superfamily, thereby lowering the barrier for the scientific community to explore SLCs as an attractive drug target class.

    • Giulio Superti-Furga
    • Daniel Lackner
    • Claire M. Steppan
    Comments & Opinion
    Nature Reviews Drug Discovery
    Volume: 19, P: 429-430