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Showing 1–2 of 2 results
Advanced filters: Author: Alvaro Lassaletta Clear advanced filters

  • Infant gliomas behave differently to their childhood or adult counterparts. Here, the authors perform a large-scale genetic analysis of these tumours, revealing genetic alterations which may offer therapeutic opportunities.

    • Ana S. Guerreiro Stucklin
    • Scott Ryall
    • Cynthia Hawkins
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • The incorporation of saturated bioisosteres of phenyl rings has emerged as an appealing strategy in drug-discovery programmes. However, stereocontrolled access to these sp3-hybridized skeletons remains elusive. Now, the enantioselective synthesis of bicyclo[2.1.1]hexanes has been achieved through a Lewis-acid-catalysed [2 + 2] photocycloaddition, making it possible to obtain different drug analogues with improved properties.

    • Pablo Garrido-García
    • Irene Quirós
    • Mariola Tortosa
    Research
    Nature Chemistry
    Volume: 17, P: 734-745