Nature Search

Targeting of the m⁶A eraser ALKBH5 suppresses stemness and chemoresistance of colorectal cancer

Activation of Wnt/β-Catenin signaling in colorectal cancer requires further mechanistic understanding. Here the authors show that the RNA N6-methyladenoine (m⁶A) eraser ALKBH5 destabilizes FAM84A mRNA to prevent β-catenin ubiquitination and degradation, contributing to colorectal cancer stemness and chemoresistance.

Heming Zhou
Huarong Chen
Jun Yu
ResearchOpen Access13 Dec 2025
Nature Communications

Volume: 17, P: 1-20
Parvimonas micra promotes colorectal tumorigenesis and is associated with prognosis of colorectal cancer patients

Liuyang Zhao
Xiang Zhang
Jun Yu
ResearchOpen Access27 Jul 2022
Oncogene

Volume: 41, P: 4200-4210
YTHDF1 targets the chemotherapy response by suppressing NOTCH1-induced stemness in colorectal cancer

Henley Cheung
Huarong Chen
Jun Yu
ResearchOpen Access22 Dec 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-14
The cholesterol uptake regulator PCSK9 promotes and is a therapeutic target in APC/KRAS-mutant colorectal cancer

Looking for metabolic-associated vulnerabilities is a promising approach for therapeutic intervention in KRAS-mutant colorectal cancer. Here, the authors show that the cholesterol-uptake regulator PCSK9 drives tumourigenesis and is a therapeutic target in KRASmutant colorectal cancer.

Chi Chun Wong
Jian-Lin Wu
Jun Yu
ResearchOpen Access08 Jul 2022
Nature Communications

Volume: 13, P: 1-15
Author Correction: Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis

Xiang Zhang
Harry Cheuk-Hay Lau
Jun Yu
Amendments and CorrectionsOpen Access21 Jan 2025
Nature Metabolism

Volume: 7, P: 230
Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis

Intestinal TM6SF2 is found to interact with fatty acid-binding protein 5 to modulate the secretion of fatty acids and the composition of the gut microbiota, thereby protecting against metabolic dysfunction-associated steatohepatitis.

Xiang Zhang
Harry Cheuk-Hay Lau
Jun Yu
ResearchOpen Access08 Jan 2025
Nature Metabolism

Volume: 7, P: 102-119
Early Pituitary-Adrenal Responses and Retinopathy of Prematurity in Very Low Birth Weight Infants

Pak Cheung Ng
Alvin Kwan Ho Kwok
Tai Fai Fok
Research01 Jan 2004
Pediatric Research

Volume: 55, P: 114-119
Peptostreptococcus anaerobius mediates anti-PD1 therapy resistance and exacerbates colorectal cancer via myeloid-derived suppressor cells in mice

Interactions between Peptostreptococcus anaerobius and host cells promote recruitment and activation of myeloid-derived suppressor cells, leading to anti-PD1 immune checkpoint inhibitor resistance and exacerbated colorectal cancer in mice.

Yali Liu
Chi Chun Wong
Jun Yu
ResearchOpen Access15 May 2024
Nature Microbiology

Volume: 9, P: 1467-1482
The artificial intelligence-based model ANORAK improves histopathological grading of lung adenocarcinoma

Yuan and colleagues developed an artificial intelligence-based method to derive growth patterns and morphological features from hematoxylin and eosin-stained slides of lung adenocarcinoma samples, for improved tumor grading and patient prognostication.

Xiaoxi Pan
Khalid AbdulJabbar
David A. Moore
ResearchOpen Access10 Jan 2024
Nature Cancer

Volume: 5, P: 347-363
MLK4 promotes glucose metabolism in lung adenocarcinoma through CREB-mediated activation of phosphoenolpyruvate carboxykinase and is regulated by KLF5

Alvin Ho-Kwan Cheung
Kit-Yee Wong
Ka-Fai To
ResearchOpen Access05 Jul 2023
Oncogenesis

Volume: 12, P: 1-14
Specific targeting of point mutations in EGFR L858R-positive lung cancer by CRISPR/Cas9

Alvin Ho-Kwan Cheung
Chit Chow
Ka-Fai To
Research10 May 2018
Laboratory Investigation

Volume: 98, P: 968-976

Search

Targeting of the m⁶A eraser ALKBH5 suppresses stemness and chemoresistance of colorectal cancer

Parvimonas micra promotes colorectal tumorigenesis and is associated with prognosis of colorectal cancer patients

YTHDF1 targets the chemotherapy response by suppressing NOTCH1-induced stemness in colorectal cancer

The cholesterol uptake regulator PCSK9 promotes and is a therapeutic target in APC/KRAS-mutant colorectal cancer

Author Correction: Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis

Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis

Early Pituitary-Adrenal Responses and Retinopathy of Prematurity in Very Low Birth Weight Infants

Peptostreptococcus anaerobius mediates anti-PD1 therapy resistance and exacerbates colorectal cancer via myeloid-derived suppressor cells in mice

The artificial intelligence-based model ANORAK improves histopathological grading of lung adenocarcinoma

MLK4 promotes glucose metabolism in lung adenocarcinoma through CREB-mediated activation of phosphoenolpyruvate carboxykinase and is regulated by KLF5

Specific targeting of point mutations in EGFR L858R-positive lung cancer by CRISPR/Cas9

Search

Quick links

Search

Filter By:

Search

Quick links