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Showing 1–5 of 5 results
Advanced filters: Author: Amal El Daibani Clear advanced filters

  • δ-Opioid receptors (δOR) are promising targets for pain management with reduced side effects. Here, the authors use a structure-based approach to design and characterize C6-Quino, a selective δOR partial agonist, highlighting its potential therapeutic relevance.

    • Balazs R. Varga
    • Sarah M. Bernhard
    • Tao Che
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Biased signaling in κ-opiod receptors (KOR) offer an attractive strategy for pain management. Here the authors identify determinants of KOR signaling bias using structural methods in combination with molecular dynamics simulations.

    • Amal El Daibani
    • Joseph M. Paggi
    • Tao Che
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Bitopic functionalized ligands based on fentanyl can target the sodium ion-binding site of the mu-opioid receptor and selectively modulate downstream signalling pathways, potentially leading to safer analgesics.

    • Abdelfattah Faouzi
    • Haoqing Wang
    • Susruta Majumdar
    Research
    Nature
    Volume: 613, P: 767-774

  • The peroxisomal β-oxidation enzyme ACOX1 increases in liver with obesity, but the physiological significance is unclear. Here, the authors show that liver-specific knockout of Acox1 leads to accumulation of omega-3 VLCFAs that promote metabolic health through activation of GPR120 in adipose tissue.

    • Dongliang Lu
    • Anyuan He
    • Irfan J. Lodhi
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • A newly discovered negative allosteric modulator of the µ-opioid receptor works together with naloxone to potently block opioid agonist signalling with reduced adverse effects.

    • Evan S. O’Brien
    • Vipin Ashok Rangari
    • Brian K. Kobilka
    Research
    Nature
    Volume: 631, P: 686-693