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Effect of General Anesthesia in Infancy on Long-Term Recognition Memory in Humans and Rats

Greg Stratmann
Joshua Lee
Simona Ghetti
Research09 Jun 2014
Neuropsychopharmacology

Volume: 39, P: 2275-2287
UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors

UM171 promotes corepressor degradation by acting as a molecular glue to induce KBTBD4–HDAC1/2 interactions with the help of inositol hexakisphosphate.

Megan J. R. Yeo
Olivia Zhang
Ning Zheng
ResearchOpen Access12 Feb 2025
Nature

Volume: 639, P: 232-240
Reactivating hippocampal-mediated memories during reconsolidation to disrupt fear

The hippocampus is a brain region critically involved in memory. In this study, the authors demonstrate that reactivating hippocampal neurons associated with positive memories can disrupt a fear response in mice.

Stephanie L. Grella
Amanda H. Fortin
Steve Ramirez
ResearchOpen Access12 Sept 2022
Nature Communications

Volume: 13, P: 1-19
Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma

Profiling the resistance landscape to PRC2 inhibitors in EZH2-mutant lymphoma with CRISPR-suppressor scanning reveals drug addiction mutations and a repressive methylation ceiling. Surpassing the ceiling with SETD2 inhibition halts lymphoma growth.

Hui Si Kwok
Allyson M. Freedy
Brian B. Liau
Research27 Mar 2023
Nature Chemical Biology

Volume: 19, P: 1105-1115
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, with subgroup analyses suggesting that the antibody profile in donor plasma is critical in determining clinical outcomes.

Philippe Bégin
Jeannie Callum
Donald M. Arnold
ResearchOpen Access09 Sept 2021
Nature Medicine

Volume: 27, P: 2012-2024

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Effect of General Anesthesia in Infancy on Long-Term Recognition Memory in Humans and Rats

UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors

Reactivating hippocampal-mediated memories during reconsolidation to disrupt fear

Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma

Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

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