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Showing 1–12 of 12 results
Advanced filters: Author: Amanda Mawson Clear advanced filters

  • This year, the latest in an annual series of Fast Radio Burst conferences was held as a fully hybrid experience from 7–11 July at McGill University in Montreal, Quebec, Canada. Marking ten years since the first repeating fast radio burst was discovered, more than 200 scientists at FRB 2025 discussed the latest results in the field and charted a course for future experiments.

    • Amanda M. Cook
    • Alice P. Curtin
    News & Views
    Nature Astronomy
    Volume: 9, P: 1760-1761

  • Exome sequencing and copy number analysis are used to define genomic aberrations in early sporadic pancreatic ductal adenocarcinoma; among the findings are mutations in genes involved in chromatin modification and DNA damage repair, and frequent and diverse somatic aberrations in genes known as embryonic regulators of axon guidance.

    • Andrew V. Biankin
    • Nicola Waddell
    • Sean M. Grimmond
    Research
    Nature
    Volume: 491, P: 399-405

  • A whole-genome sequencing analysis of 100 pancreatic ductal adenocarcinomas has discovered known and newly identified genetic drivers of pancreatic cancer; these genetic alterations can be classified into four subtypes, which raises the possibility of improved targeting of clinical treatments.

    • Nicola Waddell
    • Marina Pajic
    • Sean M. Grimmond
    Research
    Nature
    Volume: 518, P: 495-501

  • SLIT-ROBO alterations arise in pancreatic ductal adenocarcinoma (PDAC), but their role in the pancreas is unclear. Here, the authors use mouse models to show that loss of epithelial Robo2 activates the neighbouring stroma via TGF-β signalling; findings  are relevant to PDAC patients, where ROBO expression correlates with survival outcomes.

    • Andreia V. Pinho
    • Mathias Van Bulck
    • Ilse Rooman
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • The genomes of 102 primary pancreatic neuroendocrine tumours have been sequenced, revealing mutations in genes with functions such as chromatin remodelling, DNA damage repair, mTOR activation and telomere maintenance, and a greater-than-expected contribution from germ line mutations.

    • Aldo Scarpa
    • David K. Chang
    • Sean M. Grimmond
    Research
    Nature
    Volume: 543, P: 65-71

  • An integrated genomic analysis of 456 human pancreatic ductal adenocarcinomas identifies four subtypes defined by transcriptional expression profiles and show that these are associated with distinct histopathological characteristics and differential prognosis.

    • Peter Bailey
    • David K. Chang
    • Sean M. Grimmond
    Research
    Nature
    Volume: 531, P: 47-52

  • An in vivo transposon screen in a pancreatic cancer model identifies frequent inactivation of Usp9x; deletion of Usp9x cooperates with KrasG12D to accelerate rapidly pancreatic tumorigenesis in mice, validating their genetic interaction.

    • Pedro A. Pérez-Mancera
    • Alistair G. Rust
    • David A. Tuveson
    Research
    Nature
    Volume: 486, P: 266-270