Nature Search

Isozyme-selective stimulation of phospholipase C-β2 by G protein βγ-subunits

Montserrat Camps
Amanda Carozzi
Peter Gierschik
Research17 Dec 1992
Nature

Volume: 360, P: 684-686
Polygenic prediction of body mass index and obesity through the life course and across ancestries

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Roelof A. J. Smit
Kaitlin H. Wade
Ruth J. F. Loos
ResearchOpen Access21 Jul 2025
Nature Medicine

Volume: 31, P: 3151-3168
Cardiac adaptation to endurance exercise training requires suppression of GDF15 via PGC-1α

Khetarpal et al. show that the metabolic regulator PGC-1α is essential in heart muscle cells for exercise-driven cardiac growth, and that suppression of the stress-induced myokine GDF15 is required to enable cardiomyocyte adaptations to training.

Sumeet A. Khetarpal
Haobo Li
Anthony Rosenzweig
Research24 Sept 2025
Nature Cardiovascular Research

Volume: 4, P: 1277-1294
Erratum: Distinct metabolomic signatures are associated with longevity in humans

Susan Cheng
Martin G. Larson
Thomas J. Wang
Amendments and Corrections21 May 2015
Nature Communications

Volume: 6, P: 1
A saturated map of common genetic variants associated with human height

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Loïc Yengo
Sailaja Vedantam
Joel N. Hirschhorn
ResearchOpen Access12 Oct 2022
Nature

Volume: 610, P: 704-712
The power of genetic diversity in genome-wide association studies of lipids

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Research09 Dec 2021
Nature

Volume: 600, P: 675-679
Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia

There is an unmet medical need for the detection and treatment of early adenomas to prevent their progression to malignant disease. Here the authors show that orally administered E. coli Nissle 1917 can selectively colonize adenomas in mouse models and in patients as a detection tool, as well as deliver immunotherapeutics for colorectal neoplasia treatment.

Candice R. Gurbatri
Georgette A. Radford
Tal Danino
ResearchOpen Access20 Jan 2024
Nature Communications

Volume: 15, P: 1-13
Distinct metabolomic signatures are associated with longevity in humans

Metabolomic profiling provides clues at alterations in cellular biochemistry. Here, the authors perform metabolomics analyses on samples from the Framingham Heart Study, and a Danish validation cohort, to identify small-molecule biomarkers prospectively associated with longevity or ageing.

Susan Cheng
Martin G. Larson
Thomas J. Wang
Research13 Apr 2015
Nature Communications

Volume: 6, P: 1-10
Metabolite profiles and the risk of developing diabetes

Amino acid profiles could aid in diabetes risk assessment, as a five-amino-acid signature had highly significant associations with the development of future diabetes in two large, independent cohorts.

Thomas J Wang
Martin G Larson
Robert E Gerszten
Research20 Mar 2011
Nature Medicine

Volume: 17, P: 448-453
Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Amendments and Corrections26 May 2023
Nature

Volume: 618, P: E19-E20
Reduced synaptic activity and dysregulated extracellular matrix pathways in midbrain neurons from Parkinson’s disease patients

Shani Stern
Shong Lau
Fred H. Gage
ResearchOpen Access10 Aug 2022
npj Parkinson's Disease

Volume: 8, P: 1-16

Search

Isozyme-selective stimulation of phospholipase C-β2 by G protein βγ-subunits

Polygenic prediction of body mass index and obesity through the life course and across ancestries

Cardiac adaptation to endurance exercise training requires suppression of GDF15 via PGC-1α

Erratum: Distinct metabolomic signatures are associated with longevity in humans

A saturated map of common genetic variants associated with human height

The power of genetic diversity in genome-wide association studies of lipids

Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia

Distinct metabolomic signatures are associated with longevity in humans

Metabolite profiles and the risk of developing diabetes

Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Reduced synaptic activity and dysregulated extracellular matrix pathways in midbrain neurons from Parkinson’s disease patients

Search

Quick links

Search

Filter By:

Search

Quick links