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Showing 1–4 of 4 results
Advanced filters: Author: Amani A. Hariri Clear advanced filters

  • DNA nanotubes are attractive building blocks for the assembly of complex arrays. An efficient solid-state synthesis for producing surface-grafted, robust nanotubes has now been devised. Rungs are incorporated in a stepwise manner so that each one is addressable. Using fluorescent tags, the nanotube growth was visualized at the single-molecule level.

    • Amani A. Hariri
    • Graham D. Hamblin
    • Gonzalo Cosa
    Research
    Nature Chemistry
    Volume: 7, P: 295-300

  • A major challenge of enzyme-linked immunosorbent assays is discriminating true signal from non-specific binding. Here the authors present a Single-Molecule Colocalization Assay (SiMCA) which eliminates such effects, enabling reproducible detection of picomolar protein concentrations.

    • Amani A. Hariri
    • Sharon S. Newman
    • H. Tom Soh
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Aptamer switches are promising biotechnological tools but coupling of their affinity and temporal response limits their versatility. Here, the authors developed an intramolecular strand-displacement strategy that allows for independent fine-tuning of thermodynamics and kinetics of aptamer switches.

    • Brandon D. Wilson
    • Amani A. Hariri
    • H. Tom Soh
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9

  • Efforts to convert aptamers into molecular switches using rational design are often unsuccessful. Here the authors describe a massively parallel screening-based strategy whereby millions of potential aptamer switches are synthesised, sequenced and screened directly on a flow-cell.

    • Alex M. Yoshikawa
    • Alexandra E. Rangel
    • H. Tom Soh
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14