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Showing 1–6 of 6 results
Advanced filters: Author: Amelie Vromman Clear advanced filters

  • Somatic mutations in blood cells (CHIP) are linked to diseases like heart disease, but the mechanisms are unclear. Here, the authors show that different CHIP driver genes alter unique sets of plasma proteins, some of which are validated in mouse models.

    • Zhi Yu
    • Amélie Vromman
    • Pradeep Natarajan
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Despite only one chromosome differing between men and women, sex makes an enormous difference in clinical cardiovascular diseases. Recent multi-omic data expand our understanding of the underlying mechanisms that may contribute to this disparity in humans.

    • Peter Libby
    • Michael C. Honigberg
    • Amélie Vromman
    News & Views
    Nature Cardiovascular Research
    Volume: 4, P: 356-357

  • A study shows that clonal haematopoiesis of indeterminate potential is associated with an increased risk of chronic liver disease specifically through the promotion of liver inflammation and injury.

    • Waihay J. Wong
    • Connor Emdin
    • Pradeep Natarajan
    Research
    Nature
    Volume: 616, P: 747-754

  • Rauch et al. show that loss-of-function mutations in the epigenetic regulator Dnmt3a lead to accelerated atherosclerosis, as previously shown for Tet2, and that loss of either gene leads to similar changes in atheroma composition, with the emergence of a distinct population of chemokine-enriched, resident-like macrophages infiltrating the adventitia, as revealed by single-cell transcriptomics and spatial proteomic analyses.

    • Philipp J. Rauch
    • Jayakrishnan Gopakumar
    • Siddhartha Jaiswal
    Research
    Nature Cardiovascular Research
    Volume: 2, P: 805-818

  • Interleukin-18 (IL18) has a pivotal role in interferon signalling and T cell development, but increasingly recognized as an adipokine that regulates energy metabolism in fat tissue. Authors here dissect the function of IL18 signalling in the adipose compartment by targeted genomic deletion of its two receptors individually and in combination in brown and white adipose tissues.

    • Xian Zhang
    • Songyuan Luo
    • Guo-Ping Shi
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-20