Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–11 of 11 results
Advanced filters: Author: Ameya R. Kirtane Clear advanced filters

  • Preventing endosomal damage sensing or using lipids that create reparable endosomal holes reduces inflammation caused by RNA–lipid nanoparticles while enabling high RNA expression.

    • Alvin Chan
    • Ameya R. Kirtane
    • Giovanni Traverso
    ResearchOpen Access
    Nature Nanotechnology
    Volume: 20, P: 1491-1501

  • A remora-inspired mechanical underwater adhesive device adheres securely to a range of soft substrates and maintains performance under extreme pH and moisture conditions, with potential applications in biosensing and drug delivery.

    • Ziliang Kang
    • Johanna A. Gomez
    • Giovanni Traverso
    ResearchOpen Access
    Nature
    Volume: 643, P: 1271-1280

  • Poor adherence to daily antiretrovirals can significantly affect treatment efficacy, but oral long-acting antiretrovirals are currently lacking. Here, the authors develop a once-weekly oral dosage form for anti-HIV drugs, assess its pharmacokinetics in pigs, and model its impact on viral resistance and disease epidemics.

    • Ameya R. Kirtane
    • Omar Abouzid
    • Giovanni Traverso
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Increasing the molecular weight of the core of a polymeric nanoparticle significantly improves its use in gene delivery.

    • Ameya R. Kirtane
    • Jayanth Panyam
    News & Views
    Nature Nanotechnology
    Volume: 8, P: 805-806

  • Self-assembly of small drugs with organic dyes represents a facile route to synthesize nanoparticles with high drug-loading capability. Here the authors combine a machine learning approach with high-throughput experimental validation to identify which combinations of drugs and excipient lead to successful nanoparticle formation and characterize the therapeutic efficacy of two of them in vitro and in animal models.

    • Daniel Reker
    • Yulia Rybakova
    • Giovanni Traverso
    Research
    Nature Nanotechnology
    Volume: 16, P: 725-733

  • The use of drug delivery systems for the gastrointestinal tract has been faced with a number of drawbacks related to their prolonged use. Here, the authors develop a drug-loaded hydrogel with high strength to withstand long-term gastrointestinal motility and can be triggered to dissolve on demand.

    • Jinyao Liu
    • Yan Pang
    • Giovanni Traverso
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • This Review outlines the potential applications of nanotechnology-based treatments for infectious diseases, with a specific focus on the progress and challenges in developing nanomedicines against HIV, tuberculosis and malaria.

    • Ameya R. Kirtane
    • Malvika Verma
    • Giovanni Traverso
    Reviews
    Nature Nanotechnology
    Volume: 16, P: 369-384

  • Immunotherapies, predominantly immune-checkpoint inhibitors and chimaeric antigen receptor T cells, have transformed oncology. Nonetheless, these systemically administered agents have several limitations, including the risk of off-target toxicities and a lack of activity owing to an inability to overcome an immunosuppressive tumour microenvironment (TME). In this Review, the authors describe the potential to overcome these challenges using functionalized nanomaterials that are designed to release a wide range of immunotherapeutic cargoes in response to specific TME characteristics, including hypoxia, differences in pH, the presence of specific enzymes, reactive oxygen species and/or high levels of extracellular ATP.

    • Stephen W. Linderman
    • Louis DeRidder
    • Giovanni Traverso
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 22, P: 262-282