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Showing 1–7 of 7 results
Advanced filters: Author: Amie K. Boal Clear advanced filters

  • Azetidine is a four-membered aza-cycle important in medicinal and organic chemistry. This study describes a mechanism of azetidine amino acid biosynthesis from l-isoleucine or l-valine by two non-haem Fe enzymes, PolF and PolE, in the polyoxin antifungal biosynthetic pathway.

    • Yanan Du
    • Anyarat Thanapipatsiri
    • Kenichi Yokoyama
    ResearchOpen Access
    Nature Chemistry
    P: 1-10

  • X-ray crystal structures of TokK, a cobalamin- or B12-dependent radical SAM methylase, provide insight into how these enzymes use sequential radical-mediated methylations to assemble the C6 side chain of carbapenem antibiotics.

    • Hayley L. Knox
    • Erica K. Sinner
    • Squire J. Booker
    Research
    Nature
    Volume: 602, P: 343-348

  • WelO5 is an iron- and 2-oxoglutarate-dependent halogenase involved in welwitindolinone biosynthesis. A collection of X-ray crystal structures reveals the active-site geometry and ligand dynamics required for small-molecule halogenation by WelO5.

    • Andrew J Mitchell
    • Qin Zhu
    • Amie K Boal
    Research
    Nature Chemical Biology
    Volume: 12, P: 636-640