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Showing 1–7 of 7 results
Advanced filters: Author: Amir Ata Saei Clear advanced filters

  • The global identification of enzyme substrates is still challenging. Here, the authors develop a method based on proteome-wide thermal shift assays to discover enzyme substrates directly from cell lysates, identifying known and novel oxidoreductase, kinase and poly-(ADP-ribose) polymerase substrates.

    • Amir Ata Saei
    • Christian M. Beusch
    • Roman A. Zubarev
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • The protein corona on nanoparticles has potential for application in protein diagnostics. Here, the authors report on the use of small molecules to change the protein and proteoform patterns of protein corona on otherwise identical nanoparticles, which can be leveraged to significantly enhance the depth of plasma proteome profiling.

    • Ali Akbar Ashkarran
    • Hassan Gharibi
    • Morteza Mahmoudi
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Protein corona is crucial for the safety and efficacy of nanomedicines, and the protein composition of the corona layer is typically analysed using liquid chromatography-mass spectrometry. Here the authors report that the use of a uniform database search provides an opportunity for taking measures in good practice and quality control in protein corona research using mass spectroscopy technique.

    • Hassan Gharibi
    • Ali Akbar Ashkarran
    • Morteza Mahmoudi
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-9

  • Analysis of the protein corona formed around nanoparticles is important for multiple applications in nanomedicine, the methods used at core facilities used for analysis can impact the results. Here, the authors report on a study into the variability of the results obtained from 17 different core facilities and the implications of this.

    • Ali Akbar Ashkarran
    • Hassan Gharibi
    • Morteza Mahmoudi
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Anticancer drugs often have widespread effects on the cellular proteome. Here, the authors generate a proteome signature library of drug-treated cancer cell lines and develop a software tool to deconvolute drug targets and gain insights into their mechanisms of action.

    • Amir Ata Saei
    • Christian Michel Beusch
    • Roman A. Zubarev
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • It is important to understand how nanoparticles interact with biological systems and behave in vivo. This protocol describes top-down proteomics for protein corona profiling using advanced capillary zone electrophoresis–tandem mass spectrometry.

    • Seyed Amirhossein Sadeghi
    • Fei Fang
    • Morteza Mahmoudi
    Protocols
    Nature Protocols
    P: 1-34