Scandium added to Al–Cu–Mg–Ag alloys leads to an in situ phase transformation of coherent Cu-rich nanoprecipitates at elevated temperature, with Sc atoms diffusing and occupying their interstitial sites. The transformed nanoprecipitates have enhanced thermal stability while maintaining a large volume fraction and these two microstructural features enable high tensile strength of the Al alloy with creep resistance up to 400 °C.