Mahalingam et al. report findings from a first-in-human dose escalation study of the tumor microenvironment modulator VT1021 in patients with advanced solid tumors. VT1021 is found to be safe and well tolerated and the recommended phase II dose is established based on pharmacokinetic/dynamic properties and preliminary clinical activities.
- Devalingam Mahalingam
- Wael Harb
- Jing Watnick