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Advanced filters: Author: Amita R. Sahoo Clear advanced filters

Structural basis for ligand promiscuity and high signaling activity of Kaposi’s Sarcoma-associated Herpesvirus-encoded GPCR

Kaposi’s Sarcoma-associated Herpesvirus encodes ORF74, a GPCR driving oncogenesis through high basal signaling. Here, authors present cryoEM structures of both inactive and active states, revealing the structural basis for its ligand promiscuity and spontaneous activation.

Jun Bae Park
Bibekananda Sahoo
Jae U. Jung
ResearchOpen Access25 Sept 2025
Nature Communications

Volume: 16, P: 1-18
Cholesterol inhibits assembly and oncogenic activation of the EphA2 receptor

Development of a single-molecule photobleaching method, SiMPull-POP, allowed to discover that the lipid cholesterol inhibits assembly of the receptor tyrosine kinase EphA2, which prevents oncogenic signalling by the receptor.

Ryan J. Schuck
Alyssa E. Ward
Francisco N. Barrera
ResearchOpen Access11 Mar 2025
Communications Biology

Volume: 8, P: 1-13
The Model Structures of the Complement Component 5a Receptor (C5aR) Bound to the Native and Engineered ^hC5a

Amita Rani Sahoo
Richa Mishra
Soumendra Rana
ResearchOpen Access13 Feb 2018
Scientific Reports

Volume: 8, P: 1-13

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