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Showing 1–13 of 13 results
Advanced filters: Author: Amnon Koren Clear advanced filters

  • Amnon Koren recalls two papers from 2001 and 2002 that laid the foundations for a new field by using microarrays to measure DNA replication timing across the genome.

    • Amnon Koren
    Research Highlights
    Nature Reviews Genetics
    Volume: 25, P: 308

  • Aneuploidy (abnormal chromosome number) can enable rapid adaptation to stress conditions, but it also entails fitness costs from gene imbalance. Here, the authors experimentally evolve yeast while forcing maintenance of aneuploidy to identify the mechanisms that promote tolerance of aneuploidy.

    • Alaattin Kaya
    • Marco Mariotti
    • Vadim N. Gladyshev
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • The genetic basis of how cells replicate their DNA is not well understood. Here, the authors identify >1000 genetic elements that control human replication and reveal a complex epigenetic system that regulates replication origin activities.

    • Qiliang Ding
    • Matthew M. Edwards
    • Amnon Koren
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • Here the authors reveal that late replicating regions emerge from the first cell cycle post-fertilization, associate with the B compartment and nuclear lamina in maternal and paternal genomes. In bovine and mouse embryos, replication timing is set before embryonic genome activation, leading to enhanced fragility in long neuronal genes.

    • Shuangyi Xu
    • Ning Wang
    • Dieter Egli
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • A new analysis of cancer genomes identifies a decrease in the mutation burden of exons, but not introns, as compared to expectation. This difference can be explained by preferential recruitment of the DNA mismatch repair machinery to a protein modification that marks exons.

    • Dashiell J Massey
    • Amnon Koren
    News & Views
    Nature Genetics
    Volume: 49, P: 1673-1674

  • Shamil Sunyaev, Paul de Bakker and colleagues report an analysis of 11,020 de novo mutations from the whole-genome sequences of Dutch families sequenced as part of the Genome of the Netherlands project. They identify correlations related to paternal age and genic content and develop an empirical human mutation rate map.

    • Laurent C Francioli
    • Paz P Polak
    • Shamil R Sunyaev
    Research
    Nature Genetics
    Volume: 47, P: 822-826

  • An analysis of cell-type-specific epigenomic features reveals a relationship between epigenomic and mutational profiles; chromatin characteristics can explain a large proportion of mutational variance in cancer genomes and the mutational distribution can identify the probable cell type from which a given cancer originated from.

    • Paz Polak
    • Rosa Karlić
    • Shamil R. Sunyaev
    ResearchOpen Access
    Nature
    Volume: 518, P: 360-364

  • As the sample size in cancer genome studies increases, the list of genes identified as significantly mutated is likely to include more false positives; here, this problem is identified as stemming largely from mutation heterogeneity, and a new analytical methodology designed to overcome this problem is described.

    • Michael S. Lawrence
    • Petar Stojanov
    • Gad Getz
    Research
    Nature
    Volume: 499, P: 214-218