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Showing 1–6 of 6 results
Advanced filters: Author: Amy C. Rowat Clear advanced filters
  • Coenzyme Q10 is an essential lipid in aerobic respiratory metabolism and a membrane antioxidant. A new function is revealed for CoQ; as a membrane-stabilizing agent that enhances resistance of bacterial cell and liposome membranes to salt stress.

    • Catherine F Clarke
    • Amy C Rowat
    • James W Gober
    News & Views
    Nature Chemical Biology
    Volume: 10, P: 242-243
  • Extracellular matrices are viscoelastic, yet how matrix viscoelasticity regulates the epigenome remains unclear. Here, the authors show that cells cultured on viscoelastic matrices exhibit changes in the nucleoskeleton and in chromatin that enhance cell reprogramming.

    • Yifan Wu
    • Yang Song
    • Song Li
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19
  • Mechanical confinement of fibroblasts into micrometre-sized channels deforms the cell nucleus, leading to temporary nuclear lamina destablization and disassembly, loss of lamina-associated domains in chromatin and a decrease in histone and DNA methylation. These mechanically induced alterations in chromatin boost the conversion of fibroblasts into neurons and pluripotent stem cells and thus can be explored for cell engineering applications.

    • Yang Song
    • Jennifer Soto
    • Song Li
    Research
    Nature Materials
    Volume: 21, P: 1191-1199