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Showing 1–13 of 13 results
Advanced filters: Author: Amy E. M. Beedle Clear advanced filters

  • Post-translational modifications modulate nanomechanics of proteins. Here the authors use single-molecule force-clamp spectroscopy supported by density functional theory calculations to show how reactive low-weight molecular thiol compounds directly affect mechanical protein folding.

    • Amy E. M. Beedle
    • Marc Mora
    • Sergi Garcia-Manyes
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • In metalloproteins, a metal cofactor participates in the formation of the correct fold. Here the authors demonstrate—using single molecule force spectroscopy and the native copper centre as an embedded internal reporter—that the blue-copper proteins azurin and plastocyanin unfold via two independent competing pathways under force.

    • Amy E. M. Beedle
    • Ainhoa Lezamiz
    • Sergi Garcia-Manyes
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9

  • In the I-SPY2.2 trial, patients with high-risk stage 2/3 breast cancer received neoadjuvant datopotamab–deruxtecan, followed by sequential chemotherapy with or without targeted therapy, with the option of early surgical resection after each block of therapy. In a subgroup of patients, the sequential treatment strategy was superior to standard of care.

    • Katia Khoury
    • Jane L. Meisel
    • Laura J. Esserman
    Research
    Nature Medicine
    Volume: 30, P: 3728-3736

  • Mechanical force can facilitate thermodynamically unfavourable reactions. Here, the authors found that a stretching force can promote the SN2 cleavage of a protein disulfide bond by weak nucleophilic thiols, and that removing this force reverses the reaction yielding the original disulfide bond.

    • Amy E. M. Beedle
    • Marc Mora
    • Sergi Garcia-Manyes
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9

  • Laminin, an important component of the extracellular matrix supporting the epithelium, hinders the typical mechanoresponse of epithelial cells to an increase in substrate stiffness, by protecting the cell nucleus from mechanical deformation.

    • Zanetta Kechagia
    • Pablo Sáez
    • Pere Roca-Cusachs
    ResearchOpen Access
    Nature Materials
    Volume: 22, P: 1409-1420

  • Mechanical forces can be used as an alternative source of energy to increase chemical reactivity. This Review reports on the latest single-molecule measurements and how they have improved the current understanding of single-bond mechanochemistry.

    • Sergi Garcia-Manyes
    • Amy E. M. Beedle
    Reviews
    Nature Reviews Chemistry
    Volume: 1, P: 1-16

  • Cells sense mechanical forces from their environment, but the precise mechanical variable sensed by cells is unclear. Here, the authors show that cells can sense the rate of force application, known as the loading rate, with effects on YAP nuclear localization and cytoskeletal stiffness remodelling.

    • Ion Andreu
    • Bryan Falcones
    • Pere Roca-Cusachs
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • By maximizing cell–substrate force transmission, cancer cells can migrate towards either stiffer or softer substrate regions.

    • Amy E. M. Beedle
    • Pere Roca-Cusachs
    News & Views
    Nature Materials
    Volume: 21, P: 995-996

  • Mechanical force modulates the conformation and function of individual proteins, and this underpins many mechanically driven cellular processes. This Review addresses single-molecule force spectroscopy experiments conducted on proteins with a known role in mechanosensing and mechanotransduction in eukaryotic cells.

    • Amy E. M. Beedle
    • Sergi Garcia-Manyes
    Reviews
    Nature Reviews Materials
    Volume: 8, P: 10-24