Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

View all journals
Search
Log in

nature
search

Search

Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Neuropsychopharmacology (10)
Nature Communications (4)
Translational Psychiatry (2)
Nature Neuroscience (1)
Communications Biology (1)

Choose more journals

Article type Check one or more article types to show results from those article types only.

Research (18)

Subject Check one or more subjects to show results from those subjects only.

Biochemistry
Biological techniques
Biophysics
Cell biology
Chemical biology
Diseases
Drug discovery
Health care
Neuroscience
Structural biology

Date Choose a date option to show results from those dates only.

Today
Last 7 days
Last 30 days
Last 12 months
Last 2 years
Last 5 years

Custom date range

Clear all filters

Sort by:

Relevance

Date published (new to old)

Date published (old to new)

Showing 1–18 of 18 results

Advanced filters: Author: Amy Hauck Newman Clear advanced filters

Structural basis of vilazodone dual binding mode to the serotonin transporter

The serotonin transporter (SERT) is a key antidepressant target. Here, authors present a cryo-EM structure where the antidepressant vilazodone spans the main SERT binding site toward a secondary pocket and provide further insights into ligand binding.

Iris E. Kalenderoglou
Andreas Nygaard
Claus J. Loland
ResearchOpen Access18 Nov 2025
Nature Communications

Volume: 16, P: 1-15
Revealing the location and dynamics of a concealed binding site in the dopamine transporter

The number of ligand binding sites in the dopamine transporter is enigmatic due to conflicting data from structures and molecular pharmacology. Here, force spectra reveal the position and dynamics of a previously invisible transient site.

Rong Zhu
Walter Sandtner
Peter Hinterdorfer
ResearchOpen Access06 May 2025
Nature Communications

Volume: 16, P: 1-12
The binding sites for cocaine and dopamine in the dopamine transporter overlap

Beuming and colleagues determined that the binding site for cocaine overlaps with that of dopamine on the dopamine transporter. Detailed modeling and mutagenesis experiments revealed that this site is deeply buried amongst several transmembrane domains.

Thijs Beuming
Julie Kniazeff
Claus J Loland
Research22 Jun 2008
Nature Neuroscience

Volume: 11, P: 780-789
A bitopic agonist bound to the dopamine 3 receptor reveals a selectivity site

Developing subtype selective drugs for GPCRs is a major focus of research. Here, Arroyo-Urea et al. point to an unexploited selectivity site in aminergic receptors, as seen in the dopamine 3 receptor bound to a bitopic agonist.

Sandra Arroyo-Urea
Antonina L. Nazarova
Javier García-Nafría
ResearchOpen Access05 Sept 2024
Nature Communications

Volume: 15, P: 1-13
RDS-04-010: a novel atypical DAT inhibitor that inhibits cocaine taking and seeking and itself has low abuse potential in experimental animals

Omar Soler-Cedeno
Ewa Galaj
Zheng-Xiong Xi
ResearchOpen Access24 May 2025
Translational Psychiatry

Volume: 15, P: 1-11
Membrane potential shapes regulation of dopamine transporter trafficking at the plasma membrane

The dopaminergic system has important roles in a number of cognitive process. Here, the authors use detailed analysis of dopamine transporter trafficking to show its levels at the cell surface are sensitive to changes in membrane potential.

Ben D. Richardson
Kaustuv Saha
Habibeh Khoshbouei
ResearchOpen Access25 Jan 2016
Nature Communications

Volume: 7, P: 1-12
Dopamine D₃R antagonist VK4-116 attenuates oxycodone self-administration and reinstatement without compromising its antinociceptive effects

Zhi-Bing You
Guo-Hua Bi
Amy Hauck Newman
Research27 Nov 2018
Neuropsychopharmacology

Volume: 44, P: 1415-1424
The Novel Modafinil Analog, JJC8-016, as a Potential Cocaine Abuse Pharmacotherapeutic

Hai-Ying Zhang
Guo-Hua Bi
Zheng-Xiong Xi
Research07 Mar 2017
Neuropsychopharmacology

Volume: 42, P: 1871-1883
A novel fluorescently labelled ligand for the detection of DAT in immune cells by flow cytometry

Gisela Andrea Camacho-Hernandez
Amy Hauck Newman
Research24 Jul 2024
Neuropsychopharmacology

Volume: 50, P: 349-350
The selective D₃Receptor antagonist VK4-116 reverses loss of insight caused by self-administration of cocaine in rats

Marios C. Panayi
Shohan Shetty
Geoffrey Schoenbaum
ResearchOpen Access06 Apr 2024
Neuropsychopharmacology

Volume: 49, P: 1590-1599
A highly D₃R-selective and efficacious partial agonist (S)-ABS01-113 compared to its D₃R-selective antagonist enantiomer (R)-ABS01-113 as potential treatments for opioid use disorder

Ewa Galaj
Guo-Hua Bi
Amy Hauck Newman
Research25 Jul 2022
Neuropsychopharmacology

Volume: 47, P: 2309-2318
The Novel Dopamine D₃ Receptor Antagonist NGB 2904 Inhibits Cocaine's Rewarding Effects and Cocaine-Induced Reinstatement of Drug-Seeking Behavior in Rats

Zheng-Xiong Xi
Amy Hauck Newman
Eliot L Gardner
Research05 Oct 2005
Neuropsychopharmacology

Volume: 31, P: 1393-1405
R-Modafinil Attenuates Nicotine-Taking and Nicotine-Seeking Behavior in Alcohol-Preferring Rats

Xiao-Fei Wang
Guo-Hua Bi
Amy Hauck Newman
Research23 Jan 2015
Neuropsychopharmacology

Volume: 40, P: 1762-1771
Effects of selective dopamine D3 receptor partial agonist/antagonists on oxycodone self-administration and antinociception in monkeys

Kendall Woodlief
Mia I. Allen
Michael A. Nader
Research28 Apr 2023
Neuropsychopharmacology

Volume: 48, P: 1716-1723
Interactions of calmodulin kinase II with the dopamine transporter facilitate cocaine-induced enhancement of evoked dopamine release

Jacqueline D. Keighron
Jordi Bonaventura
Gianluigi Tanda
ResearchOpen Access13 Jun 2023
Translational Psychiatry

Volume: 13, P: 1-10
Phosphatidylinositol 4,5-bisphosphate (PIP₂) facilitates norepinephrine transporter dimerization and modulates substrate efflux

Phosphatidylinositol 4,5-bisphosphate (PIP₂) directly regulates norepinephrine transporter (NET) dimer stabilization at the plasma membrane. Furthermore, PIP₂ interaction with NET affects efflux.

Dino Luethi
Julian Maier
Harald H. Sitte
ResearchOpen Access17 Nov 2022
Communications Biology

Volume: 5, P: 1-11
Modafinil potentiates cocaine self-administration by a dopamine-independent mechanism: possible involvement of gap junctions

Maddalena Mereu
Takato Hiranita
Gianluigi Tanda
Research27 Apr 2020
Neuropsychopharmacology

Volume: 45, P: 1518-1526
Translating the atypical dopamine uptake inhibitor hypothesis toward therapeutics for treatment of psychostimulant use disorders

Amy Hauck Newman
Jianjing Cao
Zheng-Xiong Xi
Research11 Mar 2019
Neuropsychopharmacology

Volume: 44, P: 1435-1444