The existence of diabetic cardiomyopathy has been debated; however, substantial data now demonstrate that diabetes impairs ventricular function independent of other risk factors. Here Lebeche et al. examine the hypothesis that impaired calcium regulation and insulin signaling contribute to the detrimental effect of diabetes on cardiomyocyte function. How these two abnormalities interact to induce cardiac dysfunction is also investigated.
- Djamel Lebeche
- Amy J Davidoff
- Roger J Hajjar
