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Showing 1–4 of 4 results
Advanced filters: Author: Amy L. Kenter Clear advanced filters

  • Immunoglobulin heavy chain (IgH) diversity is shaped by locus positioning in 3D nuclear space. Here, the authors demonstrate that a highly transcribed VH gene drives Igh contact with nuclear speckles, boosting chromatin accessibility, facilitating V to DJ rearrangement and supporting allelic exclusion.

    • Saurabh Priyadarshi
    • Khalid H. Bhat
    • Amy L. Kenter
    ResearchOpen Access
    Nature Communications
    P: 1-20

  • Immunoglobulin class-switch recombination occurs in both frogs and mammals. A new study shows that the recognition mechanism used for the targeting of switch sequences might be evolutionary conserved.

    • Amy L Kenter
    • Palash Bhattacharya
    News & Views
    Nature Immunology
    Volume: 5, P: 1203-1204