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Showing 1–3 of 3 results
Advanced filters: Author: Amy L. Stiegler Clear advanced filters

  • Inhibition of DLC1 RhoGAP by p120RasGAP allows for crosstalk between the Rho and Ras pathways. Here, Chau et al. present the co-crystal structure of DLC1 RhoGAP domain and p120RasGAP SH3 domain and probe the interaction with biochemical studies.

    • Jocelyn E. Chau
    • Kimberly J. Vish
    • Amy L. Stiegler
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • A growing number of ‘pseudoenzymes’ with a regulatory role in signal transduction processes but without catalytic activity are being identified. Here, the authors identify two pseudoGTPase domains in p190RhoGAP, characterize them biochemically and structurally and show that they influence RhoGAP activity.

    • Amy L. Stiegler
    • Titus J. Boggon
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • Richard Lifton, Barbara Kazmierczak and colleagues report the identification of a new enterocolitic and autoinflammatory syndrome, which they find is caused by de novo gain-of-function mutations affecting the inflammasome protein NLRC4. Cells with mutant NLRC4 produce elevated levels of cleaved caspase-1, which leads to cell death by pyroptosis.

    • Neil Romberg
    • Khatoun Al Moussawi
    • Richard P Lifton
    Research
    Nature Genetics
    Volume: 46, P: 1135-1139