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Range extender mediates long-distance enhancer activity

The REX element is associated with long-range enhancer–promoter interactions.

Grace Bower
Ethan W. Hollingsworth
Evgeny Z. Kvon
ResearchOpen Access02 Jul 2025
Nature

Volume: 643, P: 830-838
High conservation of transcription factor binding and evidence for combinatorial regulation across six Drosophila species

Julia Zeitlinger, Alexander Stark and colleagues report genome-wide binding profiles for the transcription factor Twist across six Drosophila species. They find that the binding pattern is highly conserved across species, suggesting strong functional constraints at the enhancers that Twist regulates.

Qiye He
Anaïs F Bardet
Julia Zeitlinger
Research10 Apr 2011
Nature Genetics

Volume: 43, P: 414-420
A computational pipeline for comparative ChIP-seq analyses

Anaïs F Bardet
Qiye He
Alexander Stark
Protocols15 Dec 2011
Nature Protocols

Volume: 7, P: 45-61
Genome-wide analysis in the mouse embryo reveals the importance of DNA methylation for transcription integrity

DNA methyltrasferases play important role during mouse embryo development. Here the authors reveal the consequences of genetic inactivation of Dnmt1, Dnmt3a and Dnmt3b on the methylome and transcriptome of mouse embryos genome-wide.

Thomas Dahlet
Andrea Argüeso Lleida
Michael Weber
ResearchOpen Access19 Jun 2020
Nature Communications

Volume: 11, P: 1-14
E2F6 initiates stable epigenetic silencing of germline genes during embryonic development

DNA methylation targets CpG island promoters of germline genes to repress their expression in mouse somatic cells. Here the authors show that a transcription factor E2F6 is required to target CpG island DNA methylation and epigenetic silencing to germline genes during early mouse development.

Thomas Dahlet
Matthias Truss
Michael Weber
ResearchOpen Access11 Jun 2021
Nature Communications

Volume: 12, P: 1-14
Competition between DNA methylation and transcription factors determines binding of NRF1

The relationship between DNA methylation and transcription factor binding was studied across the genome in mouse embryonic stem cells-the study reveals that the transcription factor NRF1 is methylation-sensitive and how physiological binding of NRF1 relies on local removal of DNA methylation.

Silvia Domcke
Anaïs Flore Bardet
Dirk Schübeler
Research16 Dec 2015
Nature

Volume: 528, P: 575-579
Benchmark of computational methods to detect digenism in sequencing data

Marie-Sophie C. Ogloblinsky
Donald F. Conrad
Gaëlle Marenne
Reviews09 Apr 2025
European Journal of Human Genetics

Volume: 33, P: 831-841

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Range extender mediates long-distance enhancer activity

High conservation of transcription factor binding and evidence for combinatorial regulation across six Drosophila species

A computational pipeline for comparative ChIP-seq analyses

Genome-wide analysis in the mouse embryo reveals the importance of DNA methylation for transcription integrity

E2F6 initiates stable epigenetic silencing of germline genes during embryonic development

Competition between DNA methylation and transcription factors determines binding of NRF1

Benchmark of computational methods to detect digenism in sequencing data

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Range extender mediates long-distance enhancer activity

High conservation of transcription factor binding and evidence for combinatorial regulation across six Drosophila species

A computational pipeline for comparative ChIP-seq analyses

Genome-wide analysis in the mouse embryo reveals the importance of DNA methylation for transcription integrity

E2F6 initiates stable epigenetic silencing of germline genes during embryonic development

Competition between DNA methylation and transcription factors determines binding of NRF1

Benchmark of computational methods to detect digenism in sequencing data

Search

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