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Showing 1–4 of 4 results
Advanced filters: Author: Ana Angulo-Urarte Clear advanced filters

  • Angiogenesis requires dynamic endothelial rearrangements and relative position changes within the vascular tubes. Here the authors show that a PI3K/NUAK1/MYPT1/MLCP pathway regulates actomyosin contractility in endothelial cells and cellular rearrangement during vascular patterning.

    • Ana Angulo-Urarte
    • Pedro Casado
    • Mariona Graupera
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • Communication between endothelial leader and follower cells during collective cell migration is crucial for vascular development. Here, the authors show that PACSIN2 guides collective cell migration and angiogenesis by recruiting a protein trafficking complex to asymmetric cell-cell junctions, controlling local junction plasticity.

    • Tsveta S. Malinova
    • Ana Angulo-Urarte
    • Stephan Huveneers
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • During the formation of vascular sprouts, Notch activation inhibits proliferation of the stalk ECs via unknown mechanism. Here the authors show that PTEN represents a critical mediator of Notch anti-proliferative response in stalk cells via its phosphatase-dependent and -independent activity.

    • Helena Serra
    • Iñigo Chivite
    • Mariona Graupera
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13

  • In this Review, the authors provide an overview of the pathogenic effects of somatic activating PIK3CA mutations in congenital disorders and discuss how the interplay between genetics, cell identity and the environment explains the onset, progression and severity of these disorders with a special focus on the vasculature.

    • Ana Angulo-Urarte
    • Mariona Graupera
    Reviews
    Nature Cardiovascular Research
    Volume: 1, P: 700-714