During Drosophila metamorphosis, the γ axons of mushroom bodies are pruned and regrow into their adult morphology. The pruning process requires the ecdysone receptor EcR-B1. The authors find antagonistic transcriptional regulation of EcR-B1 by two closely related nuclear receptors, Ftz-f1 and Hr39.
- Ana Boulanger
- Christelle Clouet-Redt
- Jean-Maurice Dura