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Nature Genetics (2)

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Advanced filters: Author: Ana C. F. Bolhaqueiro Clear advanced filters

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

The authors use three-dimensional live-cell imaging of colorectal carcinoma organoids to show that chromosomal instability is widespread. Single-cell sequencing identifies heterogeneity of copy number alterations and shows clonal evolution.

Ana C. F. Bolhaqueiro
Bas Ponsioen
Geert J. P. L. Kops
Research29 Apr 2019
Nature Genetics

Volume: 51, P: 824-834
Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns

Analysis of live-cell imaging and single-cell genome sequencing data of colorectal cancer organoids identifies temporal dynamics of sub-chromosomal copy-number amplifications.

Yannik Bollen
Ellen Stelloo
Hugo J. G. Snippert
ResearchOpen Access01 Jul 2021
Nature Genetics

Volume: 53, P: 1187-1195

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Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns

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