Microbial α-L-fucosidases pertain to the glycoside hydrolases (GHs) family and catalyse the hydrolysis of terminal α-L-fucosidic linkages and transglycosylation reactions, however, prediction of their function directly from protein sequences remains challenging. Here, the authors combine a protein sequence similarity network and protein language model to explore the sequence-function space of GH29 fucosidases and substrate specificity of uncharacterised GH29 sequences.
- Ana Martínez Gascueña
- Haiyang Wu
- Nathalie Juge
