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Showing 1–3 of 3 results
Advanced filters: Author: Ana-Citlali Gradilla Clear advanced filters

  • Long, thin projections of the cell membrane known as cytonemes are required for signalling by the secreted morphogen Hedgehog. Gradilla et al.show that cytonemes carry Hedgehog-associated exovesicles, and that exovesicle formation is required for graded Hedgehog signalling.

    • Ana-Citlali Gradilla
    • Esperanza González
    • Isabel Guerrero
    Research
    Nature Communications
    Volume: 5, P: 1-13

  • The Hedgehog signalling gradient is established by dynamic signalling filopodia (cytonemes). Here, the authors show that EGF signalling may regulate cytoneme dynamics by maintaining basal plasma membrane levels of the Hedgehog co-receptor Ihog in the wing disc epithelium.

    • Vasiliki S. Lalioti
    • Ana-Citlali Gradilla
    • Isabel Guerrero
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Hedgehog (Hh) acts as a morphogen to regulate growth and cell fate specification, and several hypotheses have been proposed for its movement. Using in vivo imaging, Bischoff and colleagues find that cytonemes drive Hh movement in the wing imaginal disc epithelium and that Hh gradient establishment correlates spatially and temporally with cytoneme formation.

    • Marcus Bischoff
    • Ana-Citlali Gradilla
    • Isabel Guerrero
    Research
    Nature Cell Biology
    Volume: 15, P: 1269-1281